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Titolo:
A second trial of clozapine in a case of granulocytopenia
Autore:
Silvestrini, C; Arcangeli, T; Biondi, M; Pancheri, P;
Indirizzi:
Univ Rome La Sapienza, Psychiat Clin 3, I-00185 Rome, Italy Univ Rome La Sapienza Rome Italy I-00185 iat Clin 3, I-00185 Rome, Italy
Titolo Testata:
HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL
fascicolo: 4, volume: 15, anno: 2000,
pagine: 275 - 279
SICI:
0885-6222(200006)15:4<275:ASTOCI>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
OBSESSIVE-COMPULSIVE SYMPTOMS; COLONY-STIMULATING FACTOR; INDUCED AGRANULOCYTOSIS; SEROTONIN SYNDROME; UNSUCCESSFUL REEXPOSURE; SCHIZOPHRENIC-PATIENTS; INDUCED NEUTROPENIA; G-CSF; PAROXETINE; EOSINOPHILIA;
Keywords:
clozapine; agranulocytosis; schizophrenia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Silvestrini, C Univ Rome La Sapienza, Psychiat Clin 3, Via Univ 30, I-00185 Rome, Italy Univ Rome La Sapienza Via Univ 30 Rome Italy I-00185 Italy
Citazione:
C. Silvestrini et al., "A second trial of clozapine in a case of granulocytopenia", HUM PSYCHOP, 15(4), 2000, pp. 275-279

Abstract

It is generally believed that agranulocytosis, a major problem with clozapine treatment, will tend to occur dose-dependently once it develops in an individual. Therefore, despite clinical progress obtained, the drug has to be discontinued and treatment shifts to another drug. We report on the case of a 29-year-old woman with DSM-IV undifferentiated schizophrenia who developed agranulocytosis after 5 years of 300 mg/day clozapine treatment. The drug was withdrawn and two trials with thioridazine and olanzapine were unsuccessful. Four months after clozapine suspension, we decided to make a further trial, reintroducing clozapine titrated up to 500 mg/day. The patient'ssymptoms improved and blood leukocytes remained within the normal range after eight months. Copyright (C) 2000 John Wiley & Sons, Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 06:59:58