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Titolo:
Age-related resistance to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid-induced hippocampal lesion
Autore:
Bernal, F; Andres, N; Samuel, D; Kerkerian-LeGoff, L; Mahy, N;
Indirizzi:
Univ Barcelona, Fac Med, IDIBAPS, Unitat Bioquim, E-08036 Barcelona, SpainUniv Barcelona Barcelona Spain E-08036 Bioquim, E-08036 Barcelona, Spain CNRS, UPR Marseille, Lab Neurobiol Cellulaire & Fonct, Marseille, France CNRS Marseille France b Neurobiol Cellulaire & Fonct, Marseille, France
Titolo Testata:
HIPPOCAMPUS
fascicolo: 3, volume: 10, anno: 2000,
pagine: 296 - 304
SICI:
1050-9631(2000)10:3<296:ARTAP>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
CALCIUM-BINDING PROTEINS; GLUTAMATE-RECEPTOR SUBUNITS; EXCITATORY AMINO-ACIDS; BASAL FOREBRAIN; RAT HIPPOCAMPUS; IBOTENIC ACID; CHOLINERGIC NEURONS; NUCLEUS BASALIS; ADULT-RAT; BRAIN;
Keywords:
excitotoxicity; calcification; GABA; glutamate uptake; calbindin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
58
Recensione:
Indirizzi per estratti:
Indirizzo: Mahy, N Univ Barcelona, Fac Med, IDIBAPS, Unitat Bioquim, Casanova 143, E-08036 Barcelona, Spain Univ Barcelona Casanova 143 Barcelona Spain E-08036celona, Spain
Citazione:
F. Bernal et al., "Age-related resistance to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid-induced hippocampal lesion", HIPPOCAMPUS, 10(3), 2000, pp. 296-304

Abstract

This study compares the effects of acute alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) administration in the hippocampus in adult (3 months) and middle-aged (15 months) rats at 15 days postinjection. Injection of 1 and 2.7 mM AMPA produced dose-dependent neurodegeneration, assessed by Nissl staining; a glial reaction shown by glial fibrillary acidic protein immunocytochemistry; and calcification, revealed by alizarin red staining. Furthermore, at both doses, these alterations were significantly greater in 3-month-old rats, Finally, at AMPA 2.7 mM, no significant changes in the density of hippocampal parvalbumin- or calbindin-immunoreactive neuronsor in choline acetyltransferase, glutamate uptake, or GABA uptake activities were found in 15-month-old animals, whereas significant reductions in parvalbumin (-76%) and calbindin (-32%) immunostaining and in GABA uptake (-27%) were observed in 3-month-old animals compared to the respective sham-operated or control animals. In conclusion, this study clearly demonstrates that in rats the vulnerability of hippocampal neurons and the glial and calcification reactions to AMPA-induced injury decreased with age between 3 and15 months. Our results also indicate that hippocampal cholinergic, glutamatergic, and GABAergic systems show an adaptive response to excitotoxic damage in both adult and middle-aged animals. (C) 2000 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 10:54:18