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Titolo:
Neutrophils infiltrating the endometrium express vascular endothelial growth factor: potential role in endometrial angiogenesis
Autore:
Mueller, MD; Lebovic, DI; Garrett, E; Taylor, RN;
Indirizzi:
Univ Calif San Francisco, Dept Obstet Gynecol & Reprod Sci, Ctr Reprod Sci, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA
Titolo Testata:
FERTILITY AND STERILITY
fascicolo: 1, volume: 74, anno: 2000,
pagine: 107 - 112
SICI:
0015-0282(200007)74:1<107:NITEEV>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
MENSTRUAL-CYCLE; IMMUNOHISTOCHEMICAL LOCALIZATION; STROMAL CELLS; HUMAN UTERUS; INTERLEUKIN-8; LEUKOCYTES; ESTROGEN; LYMPHOCYTES; PREGNANCY; RECEPTORS;
Keywords:
endometrial leukocytes; neutrophil granulocytes; vascular endothelial growth factor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Taylor, RN Univ Calif San Francisco, Dept Obstet Gynecol & Reprod Sci, CtrReprod Sci, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 94143 USA
Citazione:
M.D. Mueller et al., "Neutrophils infiltrating the endometrium express vascular endothelial growth factor: potential role in endometrial angiogenesis", FERT STERIL, 74(1), 2000, pp. 107-112

Abstract

Objective(s): To identify leukocytes within the human endometrium expressing vascular endothelial growth factor (VEGF). Design(s): Prospective cohort study. Setting(s): Healthy volunteers in an academic research environment. Patients(s): Twenty-one normal cycling women without abnormal menstrual bleeding or infertility. Intervention(s): Endometrial tissue collection by Pipelle de Cornier aspiration. Main Outcome Measures(s): Histologic, immunohistochemical (CD3, CD34, CD56, CD68, neutrophil elastase, estrogen and P receptors, VEGF), and simultaneous double immunoenzymatic labeling analysis of VEGF-positive cells within the human endometrium. Result(s): Ten endometrial samples were obtained in the proliferative (cycle days 5-10) and 11 samples in the secretory phase (cycle days 15-26). Immunohistochemical analyses showed the expected distribution of the differentleukocyte cell types. Besides epithelial and stromal endometrial cells, the predominant cells that stained for VEGF were neutrophil granulocytes. Neutrophils were more abundant in the secretory phase but they expressed neither estrogen-alpha nor P receptors. Conclusion(s): Neutrophil granulocytes infiltrating the human endometrium express VEGF and regulate cyclical endometrial vascular proliferation. Ovarian steroids indirectly influence neutrophil migration. (Fertil Steril(R) 2000;74:107-12. (C) 2000 by American Society for Reproductive Medicine.)

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 13:35:40