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Titolo:
Cellular glucose-6-phosphate dehydrogenase (G6PD) status modulates the effects of nitric oxide (NO) on human foreskin fibroblasts
Autore:
Cheng, ML; Ho, HY; Liang, CM; Chou, YH; Stern, A; Lu, FJ; Chiu, DT;
Indirizzi:
Chang Gung Univ, Grad Inst Basic Med Sci, Tao Yuan, Taiwan Chang Gung Univ Tao Yuan Taiwan ad Inst Basic Med Sci, Tao Yuan, Taiwan Chang Gung Univ, Sch Med Technol, Tao Yuan, Taiwan Chang Gung Univ Tao Yuan Taiwan Univ, Sch Med Technol, Tao Yuan, Taiwan Natl Taiwan Univ, Coll Med, Dept Biochem & Internal Med, Taipei, Taiwan Natl Taiwan Univ Taipei Taiwan t Biochem & Internal Med, Taipei, Taiwan Acad Sinica, Inst Biol Chem, Taipei, Taiwan Acad Sinica Taipei TaiwanAcad Sinica, Inst Biol Chem, Taipei, Taiwan Natl Def Med Ctr, Grad Inst Life Sci, Taipei, Taiwan Natl Def Med Ctr Taipei Taiwan Ctr, Grad Inst Life Sci, Taipei, Taiwan Chang Gung Childrens Hosp, Dept Neonatol, Tao Yuan, Taiwan Chang Gung Childrens Hosp Tao Yuan Taiwan pt Neonatol, Tao Yuan, Taiwan NYU, Med Ctr, Dept Pharmacol, New York, NY 10016 USA NYU New York NY USA 10016 Med Ctr, Dept Pharmacol, New York, NY 10016 USA
Titolo Testata:
FEBS LETTERS
fascicolo: 3, volume: 475, anno: 2000,
pagine: 257 - 262
SICI:
0014-5793(20000623)475:3<257:CGD(SM>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENCODING GLUCOSE-6-PHOSPHATE-DEHYDROGENASE; GROWTH; GENE; DEFICIENCY; SUPEROXIDE; MECHANISMS; APOPTOSIS; MOLECULE;
Keywords:
nitric oxide; glucose-6-phosphate dehydrogenase; apoptosis; growth;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Chiu, DT Chang Gung Univ, Grad Inst Basic Med Sci, Tao Yuan, Taiwan Chang Gung Univ Tao Yuan Taiwan asic Med Sci, Tao Yuan, Taiwan
Citazione:
M.L. Cheng et al., "Cellular glucose-6-phosphate dehydrogenase (G6PD) status modulates the effects of nitric oxide (NO) on human foreskin fibroblasts", FEBS LETTER, 475(3), 2000, pp. 257-262

Abstract

Glucose-6-phosphate dehydrogenase (G6PD) plays an important role in cellular redox homeostasis, which is crucial for cell survival. In the present study, we found that G6PD status determines the response of cells exposed to nitric oxide (NO) donor. Treatment with NO donor, sodium nitroprusside (SNP), caused apoptosis in G6PD-deficient human foreskin fibroblasts (HFF1), whereas it was growth stimulatory in the normal counterpart (HFF3). Such effects mere abolished by NO scavengers like hemoglobin. Ectopic expression of G6PD in HFF1 cells switched the cellular response to NO from apoptosis to growth stimulation. Experiments with 1H-[1,2,4]oxadiazolo-[4,3-a]quinoxalin-1-one and 8-bromo-cGMP showed that the effects of NO on HFF1 and HFF3 cellswere independent of cGMP signalling pathway. Intriguingly, trolox prevented the SNP-induced apoptosis in HFF1 cells. These data demonstrate that G6PDplays a critical role in regulation of cell growth and survival. (C) 2000 Federation of European Biochemical Societies. Published by Elsevier ScienceB.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 03:26:50