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Titolo:
Higher short-term virologic efficacy of three-class versus two-class highly active antiretroviral salvage therapy in HIV-infected patients
Autore:
Baldanti, F; Paolucci, S; Maserati, R; Maggiolo, F; Pan, A; Castelli, F; Gulminetti, R; Comolli, G; Chiesa, A; Gerna, G;
Indirizzi:
Policlin San Matteo, IRCCS, Serv Virol, I-27100 Pavia, Italy Policlin San Matteo Pavia Italy I-27100 Serv Virol, I-27100 Pavia, Italy Policlin San Matteo, IRCCS, Lab Sperimentali Ric, I-27100 Pavia, Italy Policlin San Matteo Pavia Italy I-27100 entali Ric, I-27100 Pavia, Italy Univ Pavia, Ist Malattie Infettive, I-27100 Pavia, Italy Univ Pavia Pavia Italy I-27100 Malattie Infettive, I-27100 Pavia, Italy Osped Riuniti Bergamo, Div Malattie Infettive, I-24100 Bergamo, Italy Osped Riuniti Bergamo Bergamo Italy I-24100 tive, I-24100 Bergamo, Italy Presidio Osped Cremonese, Div Malattie Infettive, I-26100 Cremona, Italy Presidio Osped Cremonese Cremona Italy I-26100 e, I-26100 Cremona, Italy Univ Brescia, Ist Malattie Infettive & Trop, I-25100 Brescia, Italy Univ Brescia Brescia Italy I-25100 ettive & Trop, I-25100 Brescia, Italy
Titolo Testata:
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
fascicolo: 5, volume: 19, anno: 2000,
pagine: 380 - 384
SICI:
0934-9723(200005)19:5<380:HSVEOT>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
VIRUS TYPE-1 VARIANTS; PROTEASE INHIBITORS; RESISTANCE; MUTATIONS; ZIDOVUDINE; DIDANOSINE; SAQUINAVIR; NELFINAVIR; ASSAY; GENE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Gerna, G Policlin San Matteo, IRCCS, Serv Virol, I-27100 Pavia, Italy Policlin San Matteo Pavia Italy I-27100 l, I-27100 Pavia, Italy
Citazione:
F. Baldanti et al., "Higher short-term virologic efficacy of three-class versus two-class highly active antiretroviral salvage therapy in HIV-infected patients", EUR J CL M, 19(5), 2000, pp. 380-384

Abstract

The efficacy of two-class versus three-class antiretroviral salvage treatment was analyzed retrospectively in 63 HIV-infected patients in whom highlyactive antiretroviral therapy failed. Twenty-eight patients (group A) received two-class therapy, and 35 patients (group B) received three-class therapy. After 3 months of treatment, a significantly greater proportion of patients in group B (23/35, 65.7%) than in group A (8/28, 28.5%) showed a greater than or equal to 1 log(10) decrease in the plasma HIV RNA level (P = 0.0034). However, after 9-12 months, 12 of 23 (52.1%) group B responders showed viral load rebound. The results were partially explained by the finding that, at baseline, the great majority (21/27, 77.7%) of group A patients showed mutations conferring resistance to all drugs administered, whereas in group B patients' susceptibility to at least two drug classes was retained. However, after 9-12 months of therapy, most (18/20, 90%) of the shortterm responders in group B showed emergence of additional mutations that hampered long-term response.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 12:06:04