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Titolo:
Involvement of distinct signaling pathways in activin-induced increases inFSH secretion and enlargement of FSH cell population in the rat pituitary
Autore:
Katayama, T; Kyan, H; Nakashima, M; Rahayu, EY; Murakami, N; Kuroda, H;
Indirizzi:
Miyazaki Univ, Fac Agr, Dept Vet Physiol, Ctr Gene Res, Miyazaki 8892192, Japan Miyazaki Univ Miyazaki Japan 8892192 r Gene Res, Miyazaki 8892192, Japan
Titolo Testata:
ENDOCRINE JOURNAL
fascicolo: 3, volume: 47, anno: 2000,
pagine: 239 - 247
SICI:
0918-8959(200006)47:3<239:IODSPI>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
ERYTHROID-DIFFERENTIATION FACTOR; RECOMBINANT HUMAN ACTIVIN; INDUCED GROWTH ARREST; INHIBIN-BETA-A; APOPTOSIS; TUMOR; PROLIFERATION; PURIFICATION; MODULATION; EXPRESSION;
Keywords:
activin; calcium; pituitary; proliferation; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Katayama, T Miyazaki Univ, Fac Agr, Dept Vet Physiol, Ctr Gene Res, 1-1 Gakuenkibanadai Nishi, Miyazaki 8892192, Japan Miyazaki Univ 1-1 Gakuenkibanadai Nishi Miyazaki Japan 8892192
Citazione:
T. Katayama et al., "Involvement of distinct signaling pathways in activin-induced increases inFSH secretion and enlargement of FSH cell population in the rat pituitary", ENDOCR J, 47(3), 2000, pp. 239-247

Abstract

Activin-A induces increases in FSH secretion, as well as the number of immunoreactive FSH cells, in cultured rat pituitary cells. In this study, we examined whether mechanisms involved in these two actions of activin-A are identical or not, with respect to the involvement of cellular proliferation and of Ca2+-dependent signaling pathways. Treatment with activin-A (25 ng/ml) for 48 h caused increases in the number of cultured rat anterior pituitary cells that incorporated BrdU, a thymidine analog. The stimulatory effects of activin-A on FSH secretion and on the percentage of immunoreactive FSHcells were, however, not inhibited by the presence of the mitotic inhibitor cytosine arabinoside. On the other hand, the stimulatory effect of activin-A on the percentage of immunoreactive FSH cells was completely blocked inthe presence of the Ca2+/calmodulin kinase inhibitor KN-62 or the L-type Ca2+ channel blocker nicardipine. Neither of these inhibitors, however, revealed significant influence on the effect of activin-A on FSH secretion. These results suggest that activin-A exhibits its dual effect on FSH cells without causing cellular proliferation. Furthermore, activin-A appears to induce increases in FSH secretion and enlargement of FSH cell population through distinct intracellular signaling pathways, the former through Ca2+-independent and the latter through Ca2+-dependent mechanisms.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 13:37:40