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Titolo:
Predictors of cognitive decline in the early stage of probable Alzheimer'sdisease
Autore:
Marra, C; Silveri, MC; Gainotti, G;
Indirizzi:
Catholic Univ Sacred Heart, Inst Neurol, Serv Neuropsicol, I-00168 Rome, Italy Catholic Univ Sacred Heart Rome Italy I-00168 sicol, I-00168 Rome, Italy
Titolo Testata:
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS
fascicolo: 4, volume: 11, anno: 2000,
pagine: 212 - 218
SICI:
1420-8008(200007/08)11:4<212:POCDIT>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
MILD SENILE DEMENTIA; EARLY-ONSET; PROGRESSION; PATTERN; IMPAIRMENT; EDUCATION; FEATURES; AGE;
Keywords:
Alzheimer's disease; predictive factors; Alzheimer's disease subtypes;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Marra, C Catholic Univ Sacred Heart, Inst Neurol, Serv Neuropsicol, I-00168 Rome, Italy Catholic Univ Sacred Heart Rome Italy I-00168 00168 Rome, Italy
Citazione:
C. Marra et al., "Predictors of cognitive decline in the early stage of probable Alzheimer'sdisease", DEMENT G C, 11(4), 2000, pp. 212-218

Abstract

Several papers have attempted to find neurological and neuropsychological predictors of progression in Alzheimer's disease (AD) till now. Despite this quite large amount of works, different and not univocal conclusions have been reported in this field. Different study samples, different end-points and differences in statistical methods can explain much of the inconsistency in the results obtained. In our study, AD patients were examined in a very early stage of the disease to avoid any possible risk to examine subjectsat different times of evolution. All the patients underwent an extensive neuropsychological test battery twice (baseline and follow-up) spaced out over about 1 year and were divided into two groups of fast decliners (FD) andslow decliners (SD) on the basis of their rate of decay at the MMSE score. Verbal memory tests, mental control abilities and attention-demanding tasks seem to play a pivotal role in distinguishing the two groups of subjects in the early stage of the disease. Moreover, FD patients show a worse performance than SD at the baseline in most of the cognitive domains explored. In conclusion, different subtypes of AD do exist and an important predictor of progression is represented by the severity of the cognitive impairment at the onset. Copyright (C) 2000 S. Karger AG, Basel.

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Documento generato il 30/11/20 alle ore 00:17:21