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Titolo:
Glucose dependent transcriptional expression of the cre1 gene in Acremonium chrysogenum strains showing different levels of cephalosporin C production
Autore:
Jekosch, K; Kuck, U;
Indirizzi:
Lehrstuhl Allgemeine & Mol Bot, D-44780 Bochum, Germany Lehrstuhl Allgemeine & Mol Bot Bochum Germany D-44780 80 Bochum, Germany
Titolo Testata:
CURRENT GENETICS
fascicolo: 6, volume: 37, anno: 2000,
pagine: 388 - 395
SICI:
0172-8083(200006)37:6<388:GDTEOT>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
CARBON CATABOLITE REPRESSION; PENICILLIN BIOSYNTHETIC GENE; ASPERGILLUS-NIDULANS; MIG1 REPRESSOR; SACCHAROMYCES-CEREVISIAE; BINDING; PROTEIN; TRICHODERMA; CLONING; DOMAINS;
Keywords:
cephalosporin C biosynthesis; Acremonium chrysogenum; CRE1; glucose repression;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Kuck, U Lehrstuhl Allgemeine & Mol Bot, D-44780 Bochum, Germany Lehrstuhl Allgemeine & Mol Bot Bochum Germany D-44780 m, Germany
Citazione:
K. Jekosch e U. Kuck, "Glucose dependent transcriptional expression of the cre1 gene in Acremonium chrysogenum strains showing different levels of cephalosporin C production", CURR GENET, 37(6), 2000, pp. 388-395

Abstract

The cre1 gene from the beta-lactam producer Acremonium chrysogenum has been isolated and characterized in order to study glucose-dependent gene expression in this biotechnically important fungus. The deduced protein sequenceis highly similar to amino-acid sequences of other known glucose repressors from filamentous fungi, and carries conserved zinc-finger and regulatory motifs. Contrary to cre gene expression in Trichoderma reesei and Aspergillus nidulans, the transcript level of the a el gene from an A. chrysogenum wild-type strain is increased in the presence of glucose. Remarkably, the glucose-dependent transcriptional upregulation does not take place in anotherA. chrysogenum strain, which displays enhanced production of the beta-lactam antibiotic cephalosporin C. We surmise that the de-regulation of cre1 isconnected with the increased production rate in this strain.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 04:33:32