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Titolo:
MOLECULAR VARIANT M235T OF THE ANGIOTENSINOGEN GENE IS ASSOCIATED WITH ESSENTIAL-HYPERTENSION IN TAIWANESE
Autore:
CHIANG FT; HSU KL; TSENG CD; HSIAO WH; LO HM; CHERN TH; TSENG YZ;
Indirizzi:
NATL TAIWAN UNIV,COLL MED,DEPT INTERNAL MED,7 CHUN SUN S RD TAIPEI 10016 TAIWAN NATL TAIWAN UNIV,COLL MED,DEPT INTERNAL MED TAIPEI 10016 TAIWAN NATL TAIWAN UNIV,COLL MED,DEPT LAB MED TAIPEI 10016 TAIWAN NATL TAIWAN UNIV,COLL MED,GRAD INST MED TECHNOL TAIPEI 10016 TAIWAN PROVINCIAL TAO YUAN HOSP,DEPT INTERNAL MED TAYUAN TAIWAN
Titolo Testata:
Journal of hypertension
fascicolo: 6, volume: 15, anno: 1997,
pagine: 607 - 611
SICI:
0263-6352(1997)15:6<607:MVMOTA>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
AFRICAN-AMERICANS; LOCUS; LINKAGE;
Keywords:
ANGIOTENSINOGEN; ESSENTIAL HYPERTENSION; POLYMORPHISM; TAIWANESE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
F.T. Chiang et al., "MOLECULAR VARIANT M235T OF THE ANGIOTENSINOGEN GENE IS ASSOCIATED WITH ESSENTIAL-HYPERTENSION IN TAIWANESE", Journal of hypertension, 15(6), 1997, pp. 607-611

Abstract

Objective To examine the association of the molecular variants of theangiotensinogen (AGT) gene with essential hypertension in Taiwanese. Methods We conducted a case-control study concerning 151 subjects, 102hypertensives and 49 normotensives. We created a rapid mini-sequencing method based on dye-terminator cycle sequencing to simultaneously detect the M235T and T174M variants of the AGT gene for each subject. Results The genotype and allele distribution of the M235T variant differed significantly in hypertensives and normotensives (chi(2) = 11.106, P = 0.004 and chi(2) = 6.453, P = 0.011, respectively), whereas those of the T174M variant did not differ (chi(2) = 0.004, P = 0.998 and chi(2) = 0.032, P = 0.858, respectively). The odds ratio for hypertensionwas 3.64 (95% confidence interval 1.56-8.49) for subjects with the C/C genotype of the M235T variant compared with other genotypes or 2.87 (95% confidence interval 1.76-4.68) for those carrying allele C versusthose carrying allele T. Conclusion The molecular variant M235T, but not T174M, of the AGT gene is associated significantly with essential hypertension in this Taiwanese population. The genotype C/C or allele C is a risk factor for hypertension. The underlying mechanism of this association needs to be elucidated further.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 23:22:32