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Titolo:
Collagenase ointment application at 24-versus 48-hour intervals in the treatment of pressure ulcers - A randomised multicentre study
Autore:
Burgos, A; Gimenez, J; Moreno, E; Campos, J; Ardanaz, J; Talaero, C; Sanz, M; Garcia, J; Benito, S; Pastor, S; Hernandez, C; Ballesteros, E; Rivera, C;
Indirizzi:
SA, Labs Knoll, Dept Med, E-28050 Madrid, Spain SA Madrid Spain E-28050SA, Labs Knoll, Dept Med, E-28050 Madrid, Spain Hosp Sant Gervasi, Univ Geriatr, Barcelona, Spain Hosp Sant Gervasi Barcelona Spain rvasi, Univ Geriatr, Barcelona, Spain Hosp Doctor Moliner, Nursing Unit 3, Valencia, Spain Hosp Doctor Moliner Valencia Spain ner, Nursing Unit 3, Valencia, Spain Hosp Santa Clotilde, Nursing Unit, Santander, Spain Hosp Santa Clotilde Santander Spain lde, Nursing Unit, Santander, Spain Hosp San Rafael, Unit Geriatr, Granada, Spain Hosp San Rafael Granada Spain San Rafael, Unit Geriatr, Granada, Spain Hosp San Juan De Dios, Nursing Unit, Cordoba, Spain Hosp San Juan De DiosCordoba Spain Dios, Nursing Unit, Cordoba, Spain Residencia Los Nogales, Nursing Unit, Madrid, Spain Residencia Los Nogales Madrid Spain ogales, Nursing Unit, Madrid, Spain Hosp Juan Grande, Nursing Unit, Jerez De La Frontera, Spain Hosp Juan Grande Jerez De La Frontera Spain Jerez De La Frontera, Spain Hosp San Juan De Dios, Nursing Unit, Seville, Spain Hosp San Juan De DiosSeville Spain Dios, Nursing Unit, Seville, Spain
Titolo Testata:
CLINICAL DRUG INVESTIGATION
fascicolo: 6, volume: 19, anno: 2000,
pagine: 399 - 407
SICI:
1173-2563(200006)19:6<399:COAA24>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
SORES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Burgos, A SA, Labs Knoll, Dept Med, Avda Burgos 91, E-28050 Madrid, Spain SA Avda Burgos 91 Madrid Spain E-28050 1, E-28050 Madrid, Spain
Citazione:
A. Burgos et al., "Collagenase ointment application at 24-versus 48-hour intervals in the treatment of pressure ulcers - A randomised multicentre study", CLIN DRUG I, 19(6), 2000, pp. 399-407

Abstract

Objective: The purpose of the present study was to demonstrate clinical equivalence between the application of collagenase ointment at 24- and 48-hour intervals in the healing of pressure ulcers. Design and Setting: This was a multicentre, randomised, nonblind, parallelgroup study conducted at eight hospitals in Spain. Patients: A total of 102 hospitalised or institutionalised patients of either gender aged 55 years or over having had stage III pressure ulcers for <1 year were included in the study. Methods: Reduction of ulcer area by direct and indirect measurements at 1-week intervals was the primary outcome measure. The equivalence margin was established in advance at +/-20% of ulcer area. Two one-sided t-test procedures and the confidence intervals of the differences were used to test equivalence. Results: Both therapeutic regimens significantly reduced the mean ulcer areas throughout the 8-week study. In the first month the two regimens provedto be equivalent. It would have been necessary to include more patients todemonstrate equivalence in the second month of treatment. Conclusions: Once the healing process is initiated the daily collagenase ointment application can be changed to alternate days.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 20:21:20