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Titolo:
Correlates of venous catecholamine concentrations in patients with type 1 diabetes during a cold pressor test
Autore:
Luft, D; Maisch, C; Hofmann-Kruck, V; Radjaipour, M; Haring, HU;
Indirizzi:
Univ Tubingen, Med Klin & Poliklin, Dept Internal Med 4, D-72076 Tubingen,Germany Univ Tubingen Tubingen Germany D-72076 l Med 4, D-72076 Tubingen,Germany
Titolo Testata:
CLINICAL AUTONOMIC RESEARCH
fascicolo: 3, volume: 10, anno: 2000,
pagine: 131 - 137
SICI:
0959-9851(200006)10:3<131:COVCCI>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
NERVOUS-SYSTEM ACTIVITY; AUTONOMIC NEUROPATHY; PLASMA-CATECHOLAMINE; SYMPATHETIC ACTIVITY; CARDIOVASCULAR-RESPONSE; HEALTHY-SUBJECTS; INSULIN; HUMANS; STRESS; HYPERINSULINEMIA;
Keywords:
cold pressor test; diabetes mellitus; catecholamines;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Luft, D Univ Tubingen, Med Klin & Poliklin, Dept Internal Med 4, Otfried Muller Str 10, D-72076 Tubingen, Germany Univ Tubingen Otfried Muller Str 10Tubingen Germany D-72076 many
Citazione:
D. Luft et al., "Correlates of venous catecholamine concentrations in patients with type 1 diabetes during a cold pressor test", CLIN AUTON, 10(3), 2000, pp. 131-137

Abstract

In some patients with type I diabetes, various physiologic reactions during a cold presser test (CPT) are impaired. Whether this is caused by diabetic autonomic neuropathy, disturbed secretion of catecholamines, catecholamines, or disturbed blood glucose control is unknown. The authors, therefore, performed CPTs in patients with type 1 diabetes and in control subjects. They measured blood glucose concentrations, insulin concentrations, cardiac autonomic reflexes, and (before and after the CPT) venous catecholamine concentrations and analyzed correlations between these variables. Twenty-two patients with type 1 diabetes (17 men, 5 women; mean age +/- SD, 26.6 +/- 6.5y; diabetes duration, 7.6 +/- 0.7 y; glycosylated hemoglobin concentration, 7.7 +/- 2.4%) and 35 control subjects with comparable age and gender distributions were studied. Venous catecholamines were measured before and at the end of a 5-minute CPT. In patients with diabetes, only noradrenaline concentrations increased during the CPT, whereas adrenaline concentrations that were already increased at rest did not change. Adrenaline concentrations correlated inversely with insulin concentrations. In control subjects, bothadrenaline and noradrenaline increased significantly during the CPT. In both groups, the magnitude of the individual change in catecholamine concentrations was inversely correlated with the respective resting concentration. Changes in catecholamines, cardiovascular reflex tests, and blood glucose concentrations did not correlate with blood pressure changes. The authors conclude that, in patients with diabetes, resting adrenaline concentrations are related to insulin concentrations. Contrary to control subjects, in patients with diabetes, only noradrenaline increased during CPTs. In both groups, changes in catecholamine concentrations after the CPT were inversely related to the respective resting concentrations.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 09:04:43