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Titolo:
Autonomic dysfunction in Machado-Joseph disease assessed by iodine (123)-labeled metaiodobenzylguanidine myocardial scintigraphy
Autore:
Kazuta, T; Hayashi, M; Shimizu, T; Iwasaki, A; Nakamura, S; Hirai, S;
Indirizzi:
Tokyo Metropolitan Neurol Hosp, Dept Neurol, Tokyo 1830042, Japan Tokyo Metropolitan Neurol Hosp Tokyo Japan 1830042 Tokyo 1830042, Japan Ohtsu Municipal Hosp, Dept Neurol, Ohtsu, Shiga, Japan Ohtsu Municipal Hosp Ohtsu Shiga Japan Dept Neurol, Ohtsu, Shiga, Japan Hiroshima Univ, Sch Med, Dept Internal Med 3, Hiroshima, Japan Hiroshima Univ Hiroshima Japan d, Dept Internal Med 3, Hiroshima, Japan
Titolo Testata:
CLINICAL AUTONOMIC RESEARCH
fascicolo: 3, volume: 10, anno: 2000,
pagine: 111 - 115
SICI:
0959-9851(200006)10:3<111:ADIMDA>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
NERVOUS-SYSTEM; INNERVATION;
Keywords:
sympathetic nerve; iodine (123)-labeled metaiodobenzylguanidine myocardial scintigraphy; Machado-Joseph disease; single photon emission computed tomography;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Kazuta, T Tokyo Metropolitan Neurol Hosp, Dept Neurol, 2-6-1 Musashidai, Tokyo 1830042, Japan Tokyo Metropolitan Neurol Hosp 2-6-1 Musashidai Tokyo Japan 1830042
Citazione:
T. Kazuta et al., "Autonomic dysfunction in Machado-Joseph disease assessed by iodine (123)-labeled metaiodobenzylguanidine myocardial scintigraphy", CLIN AUTON, 10(3), 2000, pp. 111-115

Abstract

Iodine(123)-labeled metaiodobenzylguanidine, a radioiodinated analogue of norepinephrine, is a tracer for evaluating sympathetic Function. We used iodine(123)-labeled metaiodobenzylguanidine myocardial scintigraphy and sympathetic skin response to study autonomic nervous functions in 19 patients with Machado-Joseph disease (MJD) and 20 control subjects. Planar imaging of all the participants was done to evaluate myocardial scintigraphy. The ratio of average counts in the heart to average counts in the mediastinum was calculated For both early and delayed images, the latter of which reflects the cardiac neural uptake of the tracer. Single photon emission computed tomography also was done on 12 patients with MJD to examine regional tracer uptake to the heart. The mean ratio of counts in the heart to counts in the mediastinum in the delayed images was lower for the patients with MJD than for the control subjects (p < 0.01). Abnormal sympathetic skin response was present in 6 patients with MJD whose mean ratio of counts in the heart to counts in the mediastinum was lower than that of patients with MJD who had normal sympathetic skin response (p < 0.01). A single photon emission computed tomography study showed significantly lower accumulation of the tracer in patients with MJD than in the control subjects in the anterior lateral sectors predominantly innervated by sympathetic nerves but not in the inferior septal sectors reported to be under main innervation by parasympathetic fibers. These results show that MJD is accompanied by cardiac sympathetic dysfunction, as detected by iodine(123)-labeled metaiodobenzylguanidine myocardial scintigraphy, which appears to be correlated with sudomotor sympathetic dysfunction.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 13:16:31