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Titolo:
Effects of androgen treatment on expression of macrophage Fc gamma receptors
Autore:
Gomez, F; Ruiz, P; Lopez, R; Rivera, C; Romero, S; Bernal, JA;
Indirizzi:
Univ Cadiz, Sch Med, Dept Med, Hosp Puerto Real SAS, Cadiz, Spain Univ Cadiz Cadiz Spain ed, Dept Med, Hosp Puerto Real SAS, Cadiz, Spain
Titolo Testata:
CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY
fascicolo: 4, volume: 7, anno: 2000,
pagine: 682 - 686
SICI:
1071-412X(200007)7:4<682:EOATOE>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
IDIOPATHIC THROMBOCYTOPENIC PURPURA; IMPAIRED FUNCTION; IMMUNE CLEARANCE; IMMUNOGLOBULIN-G; SEX STEROIDS; ERYTHROCYTES; GLOBULIN; IGG; CORTICOSTEROIDS; DESTRUCTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Gomez, F Avda Paz,16 Valdelagrana, Cadiz 11500, Spain Avda Paz,16 Valdelagrana Cadiz Spain 11500 , Cadiz 11500, Spain
Citazione:
F. Gomez et al., "Effects of androgen treatment on expression of macrophage Fc gamma receptors", CL DIAG LAB, 7(4), 2000, pp. 682-686

Abstract

Macrophage Fc gamma receptors (Fc gamma Rs) play an important role in the host defense against infection and in the pathophysiology of immune cytopenias. Modulation of macrophage Fc gamma R expression is a potential therapeutic approach to immune disorders. Glucocorticoids and progesterones decrease macrophage Fc gamma R expression. We assessed the effect of treatment with androgens and antiandrogens on the expression of macrophage Fc gamma Rs using an experimental guinea pig model. Four androgens (testosterone, dihydrotestosterone, mesterolone, and danazol) and five antiandrogens (flutamide,nilutamide, cyproterone acetate, spironolactone, and finasteride) were studied. Following in vivo treatment of guinea pigs, we determined the clearance of immunoglobulin G IgG)-sensitized erythrocytes in vivo, the binding ofIgG-sensitized erythrocytes by isolated splenic macrophages, and splenic macrophage Fc gamma R cell surface expression. All of the androgens impairedthe clearance of IgG-sensitized erythrocytes by decreasing splenic macrophage Fc gamma R expression. Dihydrotestosterone and mesterolone sere more effective than testosterone or dihydrotestosterone. Flow cytometry and fluorescence microscopy with. monoclonal antibodies demonstrated that the androgens decreased the cell surface expression of Fc gamma R1,2 more than that ofFc gamma R2. Antiandrogens did not significantly alter macrophage Fc gammaR expression. Nevertheless, antiandrogens counteracted the effects of androgens on macrophage FcyR expression. These data indicate that androgens impair the clearance of IgG-coated cells by decreasing splenic macrophage FcyRexpression. Thus. androgens other than danazol are candidate drugs for thetreatment of immune disorders.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 07:09:03