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Titolo:
Enantio- and chemoselective reduction of 2,4-diketo acid derivatives with cinchona modified Pt-catalyst - Synthesis of (R)-2-hydroxy-4-phenylbutyric acid ethyl ester
Autore:
Studer, M; Burkhardt, S; Indolese, AF; Blaser, HU;
Indirizzi:
Solvias AG, CH-4002 Basel, Switzerland Solvias AG Basel Switzerland CH-4002 vias AG, CH-4002 Basel, Switzerland
Titolo Testata:
CHEMICAL COMMUNICATIONS
fascicolo: 14, , anno: 2000,
pagine: 1327 - 1328
SICI:
1359-7345(2000):14<1327:EACRO2>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
MODIFIED PLATINUM CATALYSTS; MODIFIED PT/AL2O3 CATALYSTS; ENANTIOSELECTIVE HYDROGENATION; ALPHA-KETOESTERS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
13
Recensione:
Indirizzi per estratti:
Indirizzo: Studer, M Solvias AG, R-1055-616, CH-4002 Basel, Switzerland Solvias AG R-1055-616 Basel Switzerland CH-4002 el, Switzerland
Citazione:
M. Studer et al., "Enantio- and chemoselective reduction of 2,4-diketo acid derivatives with cinchona modified Pt-catalyst - Synthesis of (R)-2-hydroxy-4-phenylbutyric acid ethyl ester", CHEM COMMUN, (14), 2000, pp. 1327-1328

Abstract

The enantio- and chemoselective hydrogenation of several 2,4-diketo acid derivatives to the corresponding 2-hydroxy compounds with cinchona modified Pt catalysts can be carried out with chemoselectivities of > 99% and enantioselectivities up to 86% (R) and 68% (S), respectively, and enrichment to >98% ee was possible for several compounds by one crystallization, opening up an efficient technical synthesis of (R)-2-hydroxy-4-phenylbutyric acid ethyl ester, a building block for several ACE inhibitors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 22:52:47