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Titolo:
Elevated interleukin (IL)-18 levels during acute graft-versus-host diseaseafter allogeneic bone marrow transplantation
Autore:
Fujimori, Y; Takatsuka, H; Takemoto, Y; Hara, H; Okamura, H; Nakanishi, K; Kakishita, E;
Indirizzi:
Hyogo Coll Med, Dept Internal Med 2, Nishinomiya, Hyogo 6638501, Japan Hyogo Coll Med Nishinomiya Hyogo Japan 6638501 miya, Hyogo 6638501, Japan Hyogo Coll Med, Dept Transfus Med, Nishinomiya, Hyogo 6638501, Japan HyogoColl Med Nishinomiya Hyogo Japan 6638501 miya, Hyogo 6638501, Japan Hyogo Coll Med, Inst Adv Med Sci, Host Def Lab, Nishinomiya, Hyogo 6638501, Japan Hyogo Coll Med Nishinomiya Hyogo Japan 6638501 miya, Hyogo 6638501, Japan Hyogo Coll Med, Dept Immunol & Med Zool, Nishinomiya, Hyogo 6638501, JapanHyogo Coll Med Nishinomiya Hyogo Japan 6638501 miya, Hyogo 6638501, Japan
Titolo Testata:
BRITISH JOURNAL OF HAEMATOLOGY
fascicolo: 3, volume: 109, anno: 2000,
pagine: 652 - 657
SICI:
0007-1048(200006)109:3<652:EI(LDA>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
GAMMA-INDUCING FACTOR; INTERFERON-GAMMA; IFN-GAMMA; T-CELLS; CYTOKINE; IL-12; EXPRESSION; ENZYME; MICE; RECIPIENTS;
Keywords:
interleukin 18; bone marrow transplantation; graft-versus-host disease; type 1 T cells; interferon gamma;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Fujimori, Y Hyogo Coll Med, Dept Internal Med 2, 1-1 Mukogawa Cho, Nishinomiya, Hyogo 6638501, Japan Hyogo Coll Med 1-1 Mukogawa Cho Nishinomiya Hyogo Japan 6638501
Citazione:
Y. Fujimori et al., "Elevated interleukin (IL)-18 levels during acute graft-versus-host diseaseafter allogeneic bone marrow transplantation", BR J HAEM, 109(3), 2000, pp. 652-657

Abstract

Acute graft-versus-host disease (aGVHD) after allogeneic bone marrow transplantation (BMT) is mediated by grafted T lymphocytes after their polarization into type 1 T cells. Interleukin (IL)-18, a novel immunoregulatory cytokine, strongly stimulates type 1 T cells, therefore we postulated that IL-18 may be involved in the pathogenesis of aGVHD. Using an enzyme-linked immunosorbent assay (ELISA), we serially measured serum levels of IL-18 in 37 patients with haematological malignancy before and after allogeneic BMT. Patients with aGVHD had high levels of IL-18 that strongly correlated with theseverity of aGVHD. We also found that they showed reduced serum levels of IL-18 after appropriate treatment or at a state of resolution. IL-18 levelswere not affected by the pretransplant regimen, engraftment or bacterial infection. Compared with circulating interferon (IFN)-gamma or IL-12 levels,serum levels of IL-18 showed a more sensitive and specific correlation with the disease status of aGVHD, These findings suggest that IL-18 may play important roles in the pathogenesis of aGVHD and that measurement of serum IL-18 levels can be useful indicator of aGVHD.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 19:50:41