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Titolo:
Increased cerebrospinal fluid Fas (Apo-1) levels in Alzheimer's disease - Relationship with IL-6 concentrations
Autore:
Martinez, M; Fernandez-Vivancos, E; Frank, A; De la Fuente, M; Hernanz, A;
Indirizzi:
Hosp Univ La Paz, Dept Biochem, Madrid 28046, Spain Hosp Univ La Paz Madrid Spain 28046 z, Dept Biochem, Madrid 28046, Spain Hosp Univ La Paz, Dept Pathol, Madrid 28046, Spain Hosp Univ La Paz Madrid Spain 28046 az, Dept Pathol, Madrid 28046, Spain Hosp Univ La Paz, Dept Neurol, Madrid 28046, Spain Hosp Univ La Paz Madrid Spain 28046 az, Dept Neurol, Madrid 28046, Spain Univ Complutense Madrid, Fac CC Biol, Dept Anim Physiol, Madrid, Spain Univ Complutense Madrid Madrid Spain , Dept Anim Physiol, Madrid, Spain
Titolo Testata:
BRAIN RESEARCH
fascicolo: 1-2, volume: 869, anno: 2000,
pagine: 216 - 219
SICI:
0006-8993(20000630)869:1-2<216:ICFF(L>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; SOLUBLE FORM; FACTOR-ALPHA; INTERLEUKIN-6; BRAIN; CYTOKINE; EXPRESSION; APOPTOSIS; IL-1-BETA; PROTEIN;
Keywords:
Fas; apoptosis; cytokines; cerebrospinal fluid; Alzheimer's disease;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Hernanz, A Hosp Univ La Paz, Dept Biochem, Madrid 28046, Spain Hosp Univ La Paz Madrid Spain 28046 chem, Madrid 28046, Spain
Citazione:
M. Martinez et al., "Increased cerebrospinal fluid Fas (Apo-1) levels in Alzheimer's disease - Relationship with IL-6 concentrations", BRAIN RES, 869(1-2), 2000, pp. 216-219

Abstract

Increasing lines of evidence suggest a role of apoptosis in the neurodegeneration associated with Alzheimer's disease, in which it has been implicated in increasing the expression of p53 and Fas. On the other hand, inflammatory cytokines have also been implicated as important factors in the progression of neuronal damage in this disease. In an attempt to investigate the possible in vivo relationship between programmed cell death and the inflammatory response in patients with dementia of the Alzheimer type (DAT), we measured the levels of soluble Fas, interleukin-1 beta (IL-1 beta) and IL-6 incerebrospinal fluid (CSF) from ten DAT patients and ten age-matched controls. Our results show a significant increase in IL-6 and soluble Fas concentrations in the CSF of DAT patients compared with those from nondemented controls. Moreover, linear regression analysis demonstrated a significant correlation (r=0.703; P<0.05) between soluble Fas and IL-6 levels in the CSF inDAT patients. These results suggest that Fas is implicated in the inflammatory response observed in Alzheimer's brains. (C) 2000 Elsevier Science BN. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 19:51:28