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Titolo:
NMDA-induced changes in a cortical network in vivo are prevented by AMPA
Autore:
Addae, JI; Evans, SM; Ali, N; Stone, TW;
Indirizzi:
Univ W Indies, Dept Preclin Sci, St Augustine, Trinid & Tobago Univ W Indies St Augustine Trinid & Tobago t Augustine, Trinid & Tobago Univ Glasgow, Inst Biomed & Life Sci, Glasgow, Lanark, Scotland Univ Glasgow Glasgow Lanark Scotland Life Sci, Glasgow, Lanark, Scotland
Titolo Testata:
BRAIN RESEARCH
fascicolo: 1-2, volume: 869, anno: 2000,
pagine: 211 - 215
SICI:
0006-8993(20000630)869:1-2<211:NCIACN>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXCITATORY AMINO-ACIDS; RAT CEREBRAL-CORTEX; GLUTAMATE RECEPTORS; HIPPOCAMPAL-NEURONS; PURKINJE-CELLS; SPINAL-CORD; DESENSITIZATION; CYCLOTHIAZIDE; CA2+; VULNERABILITY;
Keywords:
NMDA; AMPA; neocortex; desensitisation; network; adaptation; neocortex; evoked potential; cyclothiazide;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Addae, JI Univ W Indies, Dept Preclin Sci, St Augustine, Trinid & Tobago Univ W Indies St Augustine Trinid & Tobago e, Trinid & Tobago
Citazione:
J.I. Addae et al., "NMDA-induced changes in a cortical network in vivo are prevented by AMPA", BRAIN RES, 869(1-2), 2000, pp. 211-215

Abstract

Analogues of glutamic acid including N-methyl-D-aspartic acid (NMDA) depolarise neurones of the cerebral cortex in vivo and thus change the size of the somatosensory evoked potentials (SEPs). The potentials recover rapidly despite maintained superfusion with NMDA, suggesting a form of neuronal desensitisation or network adaptation. In this study potentials were evoked at the cortical surface by electrical stimulation of the contralateral forepawand compounds applied topically to the cortical surface by a cortical cup. NMDA at 50-250 mu M caused a concentration-dependent decrease in the amplitude of the SEPs, with the highest concentration always abolishing them. AMPA at 50 mu M did not affect evoked potentials when applied alone, but prevented the NMDA. Such AMPA-NMDA interactions were inhibited by 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) and enhanced by cyclothiazide (which prevents AMPA desensitisation). Superfusion with potassium did not change sensitivity to NMDA. These results suggest that, in the rat cerebral cortex in vivo, activation of AMPA receptors can induce a loss of the network response toactivation of NMDA receptors. Such a phenomenon may have physiological andtherapeutic implications. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 12:47:57