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Titolo:
Cardiac calcineurin during transition from hypertrophy to heart failure inrats
Autore:
Hayashida, W; Kihara, Y; Yasaka, A; Sasayama, S;
Indirizzi:
Kyoto Univ, Grad Sch Med, Dept Cardiovasc Med, Sakyo Ku, Kyoto 6068507, Japan Kyoto Univ Kyoto Japan 6068507 ovasc Med, Sakyo Ku, Kyoto 6068507, Japan
Titolo Testata:
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
fascicolo: 1, volume: 273, anno: 2000,
pagine: 347 - 351
SICI:
0006-291X(20000624)273:1<347:CCDTFH>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANGIOTENSIN-CONVERTING ENZYME; PRESSURE-OVERLOAD HYPERTROPHY; II RECEPTORS; CYCLOSPORINE; MICE; TRANSCRIPTION; ACTIVATION; INHIBITION; FAMILY; AT(1);
Keywords:
calcineurin; Dahl salt-sensitive rats; hypertrophy; heart failure; cyclosporin A; ACE inhibitor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Kihara, Y Kyoto Univ, Grad Sch Med, Dept Cardiovasc Med, Sakyo Ku, 54 Shogoin Kawaharacho, Kyoto 6068507, Japan Kyoto Univ 54 Shogoin Kawaharacho Kyoto Japan 6068507 07, Japan
Citazione:
W. Hayashida et al., "Cardiac calcineurin during transition from hypertrophy to heart failure inrats", BIOC BIOP R, 273(1), 2000, pp. 347-351

Abstract

We studied an alteration of calcineurin expression in the heart and its modification by cyclosporin A and an ACE inhibitor, temocapril, using Dahl salt-sensitive (DS) rats with hypertensive left ventricular hypertrophy (LVH)and congestive heart failure (CHF). Calcineurin protein expression in the LV myocardium was increased in the LVH stage, but then decreased during CBFtransition. Chronic cyclosporin A treatment (10 mg/kg/day), which inhibitscalcineurin activity, could not block the increases of LV weight and dimensions and did not improve the LV systolic function during the CHF transition. In contrast, chronic temocapril treatment (20 mg/kg/day) restored the downregulation of calcineurin expression, but progression of the hypertrophicprocess was inhibited. Therefore, cardiac calcineurin is increased in the hypertensive LVH and may he involved in the development of the adaptive hypertrophic process. However, calcineurin expression is downregulated during CHF transition and may no longer play a major role in the pathogenesis of myocardial hypertrophy in the failing hearts. (C) 2000 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 23:34:51