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Titolo:
Neuropsychological and conditioned blocking performance in patients with schizophrenia: assessment of the contribution of neuroleptic dose, serum levels and dopamine D-2-receptor occupancy
Autore:
Oades, RD; Rao, ML; Bender, S; Sartory, G; Muller, BW;
Indirizzi:
Univ Clin Child & Adolescent Psychiat & Psychothe, D-45147 Essen, Germany Univ Clin Child & Adolescent Psychiat & Psychothe Essen Germany D-45147 Univ Clin Psychiat & Psychotherapy, Essen, Germany Univ Clin Psychiat & Psychotherapy Essen Germany herapy, Essen, Germany Univ Bonn, Dept Psychiat & Psychotherapy, D-5300 Bonn, Germany Univ Bonn Bonn Germany D-5300 hiat & Psychotherapy, D-5300 Bonn, Germany Univ Dept Clin Psychol, Wuppertal, Germany Univ Dept Clin Psychol Wuppertal Germany in Psychol, Wuppertal, Germany
Titolo Testata:
BEHAVIOURAL PHARMACOLOGY
fascicolo: 3-4, volume: 11, anno: 2000,
pagine: 317 - 330
SICI:
0955-8810(200006)11:3-4<317:NACBPI>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
D-2 RECEPTOR OCCUPANCY; OBSESSIVE-COMPULSIVE DISORDER; MONOAMINE METABOLISM; LATENT INHIBITION; TREATED PATIENTS; YOUNG-PATIENTS; OLANZAPINE; RISPERIDONE; CLOZAPINE; MEMORY;
Keywords:
dopamine; dopamine D-2 receptor; neuroleptic; antipsychotic dose; serum level; schizophrenia; attention; gender; conditioned blocking;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
61
Recensione:
Indirizzi per estratti:
Indirizzo: Oades, RD Univ Clin Child & Adolescent Psychiat & Psychothe, Virchowstr 174, D-45147Essen, Germany Univ Clin Child & Adolescent Psychiat & Psychothe Virchowstr 174 Essen Germany D-45147
Citazione:
R.D. Oades et al., "Neuropsychological and conditioned blocking performance in patients with schizophrenia: assessment of the contribution of neuroleptic dose, serum levels and dopamine D-2-receptor occupancy", BEHAV PHARM, 11(3-4), 2000, pp. 317-330

Abstract

Patients with schizophrenia show impairments of attention and neuropsychological performance, but the extent to which this is attributable to antipsychotic medication remains largely unexplored. We describe here the putativeinfluence of the dose of antipsychotic medication (chlorpromazine equivalents, CPZ), the antipsychotic serum concentration of dopamine (DA) D-2-blocking activity and the approximated central dopamine D-2-receptor occupancy (DA D-2-occupancy), on conditioned blocking (CB) measures of attention and performance on a neuropsychological battery, in 108 patients with schizophrenia (compared with 62 healthy controls). Antipsychotic serum concentration and D-2-occupancy were higher in patients with a paranoid versus non-paranoid diagnosis, and in female versus male patients (independent of symptom severity). Controlling for D-2-occupancy removed the difference between high CB in paranoid and impaired low CB in non-paranoid patients. Similar partial correlations for antipsychotic drug dose and serum levels of DA D-2-blocking activity with performance of the trail-making and picture completion tests (negative) and the block-design task (positive) showed the functional importance of DA-related activity. High estimates of central DA D-2-occupancy were related to impaired verbal fluency but were associated with improvedrecall of stories, especially in paranoid patients. This, the first study of its kind, tentatively imputes a role for DA D-2-related activity in leftfrontal (e.g. CB, verbal fluency) and temporal lobe functions (verbal recall) as well as in some non-verbal abilities mediated more in the right hemisphere in patients with schizophrenia. (C) 2000 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 10:19:53