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Titolo:
Low-dose clozapine pretreatment partially prevents haloperidol-induced deficits in conditioned active avoidance
Autore:
Murphy, CA; Feldon, J;
Indirizzi:
ETH Zurich, Lab Behav Biol, Zurich, Switzerland ETH Zurich Zurich Switzerland rich, Lab Behav Biol, Zurich, Switzerland
Titolo Testata:
BEHAVIOURAL PHARMACOLOGY
fascicolo: 3-4, volume: 11, anno: 2000,
pagine: 307 - 316
SICI:
0955-8810(200006)11:3-4<307:LCPPPH>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
ATYPICAL ANTIPSYCHOTIC-DRUGS; EARLY GENE-EXPRESSION; INDUCED CATALEPSY; NEUROLEPTIC DRUGS; ANTICHOLINERGIC DRUGS; FOS EXPRESSION; RATS; RECEPTORS; MECHANISMS; BLOCKADE;
Keywords:
haloperidol; clozapine; antipsychotics; neuroleptics; avoidance; catalepsy; extrapyramidal motor symptoms; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
57
Recensione:
Indirizzi per estratti:
Indirizzo: Murphy, CA ETH Zurich, Lab Behav Neurobiol, Schorenstr 16, CH-8603 Schwerzenbach, Switzerland ETH Zurich Schorenstr 16 Schwerzenbach Switzerland CH-8603 and
Citazione:
C.A. Murphy e J. Feldon, "Low-dose clozapine pretreatment partially prevents haloperidol-induced deficits in conditioned active avoidance", BEHAV PHARM, 11(3-4), 2000, pp. 307-316

Abstract

The effectiveness of neuroleptics in disrupting conditioned active avoidance has led to the widespread use of this test as an index of antipsychotic efficacy, whereas the tendency for these drugs to induce catalepsy is believed to reflect their propensity to cause extrapyramidal motor side-effects. Although the typical neuroleptic haloperidol produces catalepsy as well asprofound deficits in conditioned active avoidance, the atypical neuroleptic clozapine does not induce catalepsy and is less effective than haloperidol in disrupting active avoidance. Furthermore, clozapine pretreatment prevents haloperidol-induced catalepsy. We investigated whether clozapine pretreatment might also reduce the disruptive effects of haloperidol on two-way active avoidance. We assessed the avoidance acquisition of the following drug treatment groups in which all animals received two injections prior to testing: vehicle + vehicle, vehicle + haloperidol (0.1 mg/kg, i.p.), clozapine (2.5, 5.0 or 10 mg/kg, i.p.) + haloperidol (0.1 mg/kg, i.p.), or clozapine (2.5, 5.0 or 10 mg/kg, i.p.) + vehicle. Haloperidol-pretreated animals showed markedly impaired active avoidance, deficits which were improved by 2.5 and 5 mg/kg but not by 10 mg/kg clozapine pretreatment. These data suggest that the disruptive effects of haloperidol on conditioned active avoidance partially mirror its capacity to induce catalepsy and extrapyramidal motor symptoms. Furthermore, this study indicates that clozapine may be effective in reducing motor side-effects caused by typical neuroleptics. (C) 2000 Lippincott Williams & Wilkins.

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Documento generato il 20/01/20 alle ore 04:53:37