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Titolo:
Spatial and associative learning deficits induced by neonatal excitotoxic hippocampal damage in rats: further evaluation of an animal model of schizophrenia
Autore:
Le Pen, G; Grottick, AJ; Higgins, GA; Martin, JR; Jenck, F; Moreau, JL;
Indirizzi:
F Hoffmann La Roche & Co Ltd, Preclin CNS Res, Div Pharma, CH-4070 Basel, Switzerland F Hoffmann La Roche & Co Ltd Basel Switzerland CH-4070 asel, Switzerland
Titolo Testata:
BEHAVIOURAL PHARMACOLOGY
fascicolo: 3-4, volume: 11, anno: 2000,
pagine: 257 - 268
SICI:
0955-8810(200006)11:3-4<257:SAALDI>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
MORRIS WATER MAZE; ENTORHINAL CORTEX LESIONS; WORKING-MEMORY; VENTRAL HIPPOCAMPUS; PREPULSE INHIBITION; PERIRHINAL CORTEX; STARTLE REFLEX; SOCIAL-BEHAVIOR; IBOTENIC ACID; ADULT RATS;
Keywords:
schizophrenia; animal model; prepulse inhibition; Morris water maze; passive and active avoidance; ibotenic acid; neonatal lesion; ventral hippocampus; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
77
Recensione:
Indirizzi per estratti:
Indirizzo: Le Pen, G F Hoffmann La Roche & Co Ltd, Preclin CNS Res, Div Pharma, PRBN-B 72-119, CH-4070 Basel, Switzerland F Hoffmann La Roche & Co Ltd PRBN-B 72-119 Basel Switzerland CH-4070
Citazione:
G. Le Pen et al., "Spatial and associative learning deficits induced by neonatal excitotoxic hippocampal damage in rats: further evaluation of an animal model of schizophrenia", BEHAV PHARM, 11(3-4), 2000, pp. 257-268

Abstract

Neonatal ventral hippocampal lesions in the rat result in post-pubertal onset of behavioural abnormalities, modelling some aspects of schizophrenia. We further assessed the behavioural effects of neonatal lesions in rats in a variety of cognitive tasks and in the prepulse inhibition (PPI) of startle response paradigm. Prepubescent, lesioned rats exhibited startle responses and PPI similar to controls whereas, at adulthood, they showed a deficit in PPI. Lesioned rats acquired both passive and active avoidance responses. However, compared to controls, they showed a deficit in passive avoidance retention and in acquisition of active avoidance responses. In a cued Morris water-maze task, lesioned rats demonstrated adequate sensorimotor functions and appropriate motivation to escape from water. However, they were impaired in place learning and in remembering the location of a submerged platform. In conclusion, neonatal ventral hippocampal lesions result in the post-pubertal emergence of long-lasting deficits in sensorimotor gating and in the capacity to acquire and retain information in tests of spatial and avoidance learning. Therefore, this neurodevelopmental model of schizophrenia seems to exhibit an interesting degree of validity in possibly simulating some cognitive impairments and sensorimotor gating deficits frequently observed in psychotic patients. (C) 2000 Lippincott William & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 18:32:32