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Titolo:
AEROSOLIZED AMILORIDE - DOSE-EFFECT ON NASAL BIOELECTRIC PROPERTIES, PHARMACOKINETICS, AND EFFECT ON SPUTUM EXPECTORATION IN PATIENTS WITH CYSTIC-FIBROSIS
Autore:
HOFMANN T; SENIER I; BITTNER P; HULS G; SCHWANDT HJ; LINDEMANN H;
Indirizzi:
JLU KINDERKLIN,FEULGENSTR 12 D-35385 GIESSEN GERMANY JLU KINDERKLIN D-35385 GIESSEN GERMANY
Titolo Testata:
Journal of aerosol medicine
fascicolo: 2, volume: 10, anno: 1996,
pagine: 147 - 158
SICI:
0894-2684(1996)10:2<147:AA-DON>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
INHALATION; EPITHELIA;
Keywords:
AEROSOLIZED AMILORIDE; TRANSEPITHELIAL POTENTIAL DIFFERENCE; SERUM AMILORIDE LEVEL; HIGH DOSE AMILORIDE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
T. Hofmann et al., "AEROSOLIZED AMILORIDE - DOSE-EFFECT ON NASAL BIOELECTRIC PROPERTIES, PHARMACOKINETICS, AND EFFECT ON SPUTUM EXPECTORATION IN PATIENTS WITH CYSTIC-FIBROSIS", Journal of aerosol medicine, 10(2), 1996, pp. 147-158

Abstract

Aerosolized amiloride normalizes the excessive sodium absorption across cystic fibrosis (CF) respiratory epithelium. The aims of this studywere to assess the dose-effect relationship and the duration for which amiloride inhibits Na+ transport, to determine acute and chronic pharmacokinetics, and to test the effect of acute aerosolized amiloride on the amount of sputum expectorated. The effect of inhaled amiloride was assessed principally by nasal potential difference (PD) measurements. Amiloride serum levels were measured in 23 patients after inhalation of different doses of aerosolized amiloride. Twenty CF patients inhaled amiloride (10(-3) M) or a placebo in a double-blinded, randomized order, and sputum production was quantitated. The results of this study showed that maximal initial PD inhibition was achieved by 6 x 10(-3)M of amiloride. The duration of inhibition of PD (effective time until return to 50% Delta PD [ET50] after nasal administration) was dose dependent (10(-3) M, 39 +/- 0.8 minutes; 10(-2) M; 133 +/- 14 minutes). Amiloride serum levels were below 2.5 ng/ml in 20 of 28 patients; levels were above 5 ng/ml only within 4 hours after high dose inhalation (10(-2) M). In the double-blinded, crossover study, more sputum was expectorated after amiloride inhalation as compared with that after a placebo (P < 0.05). In conclusion, the bioelectric effects of amiloride and serum levels after inhalation are dose dependent, and amiloride iseffective at inducing sputum expectoration in CF.

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