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Titolo:
Animal models of deficient sensorimotor gating: what we know, what we think we know, and what we hope to know soon
Autore:
Swerdlow, NR; Braff, DL; Geyer, MA;
Indirizzi:
Univ Calif San Diego, Sch Med, Dept Psychiat, La Jolla, CA 92093 USA Univ Calif San Diego La Jolla CA USA 92093 ychiat, La Jolla, CA 92093 USA
Titolo Testata:
BEHAVIOURAL PHARMACOLOGY
fascicolo: 3-4, volume: 11, anno: 2000,
pagine: 185 - 204
SICI:
0955-8810(200006)11:3-4<185:AMODSG>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACOUSTIC STARTLE RESPONSE; PEDUNCULOPONTINE TEGMENTAL NUCLEUS; INFORMATION-PROCESSING DEFICITS; OBSESSIVE-COMPULSIVE DISORDER; PREPULSE INHIBITION DEFICITS; MEDIAL PREFRONTAL CORTEX; SCHIZOPHRENIC-PATIENTS; RAT STRAINS; DOPAMINE-RECEPTORS; FACIAL NUCLEUS;
Keywords:
animal model; antipsychotics; dopamine; prepulse inhibition; schizophrenia; sensorimotor; startle; strain differences;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
153
Recensione:
Indirizzi per estratti:
Indirizzo: Swerdlow, NR Univ Calif San Diego, Sch Med, Dept Psychiat, 0804,9500 Gillman Dr, La Jolla, CA 92093 USA Univ Calif San Diego 0804,9500 Gillman Dr La Jolla CA USA 92093
Citazione:
N.R. Swerdlow et al., "Animal models of deficient sensorimotor gating: what we know, what we think we know, and what we hope to know soon", BEHAV PHARM, 11(3-4), 2000, pp. 185-204

Abstract

Sensorimotor gating of the startle reflex can be studied in humans and laboratory animals using measures of prepulse inhibition (PPI) of the startle reflex. PPI is reduced in patients with specific neuropsychiatric disordersand in rats after manipulation of the limbic cortex, striatum, pallidum orpontine tegmentum. Studies are rapidly identifying the neurochemical and neuroanatomical substrates regulating PPI in laboratory animals; this detailed circuit information has been used as a 'blueprint' to identify possible candidate substrates responsible for PPI deficits in psychiatrically disordered humans. In parallel, studies have also begun to assess the homology ofpharmacological effects on PPI across species, as an initial step towards translating detailed neural circuit information from rats to humans. Despite this rapid progress, there is an increasing danger of overlooking important methodological and interpretative issues that could impact either positively or negatively on the ultimate utility of models based on measures of PPI. Some of these issues ranging from the cross-species methods for quantifying specific variables to the relevance of genetic drift to animal and human studies of PPI - and their implications for future studies are the focusof this review. (C) 2000 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/01/20 alle ore 07:15:47