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Titolo:
[F-18] FLUORODOPA PET SHOWS STRIATAL DOPAMINERGIC DYSFUNCTION IN JUVENILE NEURONAL CEROID-LIPOFUSCINOSIS
Autore:
RUOTTINEN HM; RINNE JO; HAAPARANTA M; SOLIN O; BERGMAN J; OIKONEN VJ; JARVELA I; SANTAVUORI P;
Indirizzi:
UNIV TURKU,DEPT NEUROL FIN-20520 TURKU FINLAND ABO AKAD UNIV,TURKU PET CTR,RADIOPHARMACEUT CHEM & ACCELERATOR LAB TURKU FINLAND TURKU PET CTR,PET UNIT TURKU FINLAND NATL PUBL HLTH INST,DEPT HUMAN MOL GENET HELSINKI FINLAND UNIV HELSINKI,CHILDRENS HOSP HELSINKI FINLAND
Titolo Testata:
Journal of Neurology, Neurosurgery and Psychiatry
fascicolo: 6, volume: 62, anno: 1997,
pagine: 622 - 625
SICI:
0022-3050(1997)62:6<622:[FPSSD>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; PARKINSONS-DISEASE;
Keywords:
DOPAMINE; FLUORODOPA POSITRON EMISSION TOMOGRAPHY; NEURONAL CEROID LIPOFUSCINOSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
H.M. Ruottinen et al., "[F-18] FLUORODOPA PET SHOWS STRIATAL DOPAMINERGIC DYSFUNCTION IN JUVENILE NEURONAL CEROID-LIPOFUSCINOSIS", Journal of Neurology, Neurosurgery and Psychiatry, 62(6), 1997, pp. 622-625

Abstract

Objectives-To investigate whether nigrostriatal dopaminergic hypofunction is related to the extrapyramidal symptoms in patients with juvenile neuronal ceroid lipofuscinosis (JNCL). Methods-Nine patients with JNCL and seven healthy controls were studied using [F-18]fluorodopa PET. Results-In the patients with JNCL [F-18]fluorodopa uptake (K-i(occ))in the putamen was 60% of the control mean and the corresponding figure in the caudate nucleus was 79%. There was a weak correlation between putamen K-i(occ) values and extrapyramidal symptoms of the patients evaluated by the motor part of the unified Parkinson's disease rating scale (r = -0.57, P < 0.05). The overall severity of the disease also displayed a negative correlation with the K-i(occ) values in the putamen (r = -0.71, P < 0.05). Conclusion-In patients with JNCL there was reduced striatal [F-14]fluorodopa uptake, which had a modest correlation with extrapyramidal symptoms. Dysfunction of nigrostriatal dopaminergic neurons is therefore not the only cause of the patients' extrapyramidal symptoms, but degenerative changes in other brain areas are alsocontributory.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 12:27:22