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Titolo:
Comparison of the echinocandin caspofungin with amphotericin B for treatment of histoplasmosis following pulmonary challenge in a murine model
Autore:
Kohler, S; Wheat, LJ; Connolly, P; Schnizlein-Bick, C; Durkin, M; Smedema, M; Goldberg, J; Brizendine, E;
Indirizzi:
Histoplasmosis Reference Lab, Indianapolis, IN 46202 USA Histoplasmosis Reference Lab Indianapolis IN USA 46202 olis, IN 46202 USA Indiana Univ, Sch Med, Dept Vet Affairs Hosp, Indianapolis, IN USA IndianaUniv Indianapolis IN USA Vet Affairs Hosp, Indianapolis, IN USA Indiana Univ, Sch Med, Dept Med, Indianapolis, IN USA Indiana Univ Indianapolis IN USA Sch Med, Dept Med, Indianapolis, IN USA Indiana Univ, Sch Med, Dept Pathol, Indianapolis, IN USA Indiana Univ Indianapolis IN USA Med, Dept Pathol, Indianapolis, IN USA
Titolo Testata:
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
fascicolo: 7, volume: 44, anno: 2000,
pagine: 1850 - 1854
SICI:
0066-4804(200007)44:7<1850:COTECW>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
IN-VITRO; ANTIFUNGAL AGENT; PNEUMOCANDIN ANTIFUNGAL; CRYPTOCOCCUS-NEOFORMANS; MK-0991 L-743,872; ASPERGILLOSIS; CANDIDIASIS; FLUCONAZOLE; CAPSULATUM; L-733560;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Wheat, LJ Histoplasmosis Reference Lab, 1001 W 10th St,OPW 430, Indianapolis, IN 46202 USA Histoplasmosis Reference Lab 1001 W 10th St,OPW 430 Indianapolis IN USA 46202
Citazione:
S. Kohler et al., "Comparison of the echinocandin caspofungin with amphotericin B for treatment of histoplasmosis following pulmonary challenge in a murine model", ANTIM AG CH, 44(7), 2000, pp. 1850-1854

Abstract

Twenty clinical isolates of Histoplasma capsulatum were tested for their in vitro susceptibilities to caspofungin in comparison to those to amphotericin B by following National Committee for Clinical Laboratory Standards guidelines for yeasts, The mean MICs were 16.6 mu g/ml (range, 8 to 32 mu g/ml) for caspofungin and 0.56 mu g/ml (range, 0.5 to 1.0 mu g/ml) for amphotericin B. Survival experiments used a 10(5) dose in a pulmonary challenge model with B6C3F(1) mice. All mice that received amphotericin B at 2 mg/kg of body weight every other day (q.o.d.), 30% of mice that received caspofunginat 8 mg/kg/day, and 20% of mice that received caspofungin at 4 mg/kg/day survived to day lj, while mice that received caspofungin at 2 mg/kg/day and all control mice that received the vehicle died by day 14. Amphotericin B at 2 mg/kg q.o.d. markedly reduced the fungal burden in the lungs and spleens, as measured by Histoplasma antigen detection techniques and quantitativecultures, for each comparison. Caspofungin at 10 mg/kg twice a day (b.i.d.) did not reduce the fungal burden, as measured by antigen detection techniques, but slightly reduced the levels of fungi in both the lungs and spleens, as determined by quantitative cultures. Caspofungin at 5 mg/kg b.i.d. did not affect fungal burden. Overall, caspofungin had only a slight effect on survival or fungal burden.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 15:16:47