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Titolo:
Milrinone for long-term pharmacologic support of the status 1 heart transplant candidates
Autore:
Canver, CC; Chanda, J;
Indirizzi:
Albany Med Coll, Div Cardiothorac Surg, Albany, NY 12208 USA Albany Med Coll Albany NY USA 12208 rdiothorac Surg, Albany, NY 12208 USA
Titolo Testata:
ANNALS OF THORACIC SURGERY
fascicolo: 6, volume: 69, anno: 2000,
pagine: 1823 - 1826
SICI:
0003-4975(200006)69:6<1823:MFLPSO>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTRAVENOUS MILRINONE; WAITING LIST; LUNG-TRANSPLANTATION; INOTROPIC THERAPY; FAILURE; VASODILATOR; INHIBITION; DOBUTAMINE; REGISTRY; TIME;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Canver, CC Albany Med Coll, Div Cardiothorac Surg, 47 New Scotland Ave,Mail Code 55, Albany, NY 12208 USA Albany Med Coll 47 New Scotland Ave,Mail Code 55 Albany NY USA 12208
Citazione:
C.C. Canver e J. Chanda, "Milrinone for long-term pharmacologic support of the status 1 heart transplant candidates", ANN THORAC, 69(6), 2000, pp. 1823-1826

Abstract

Background. We determined the efficacy of long-term therapy with milrinonealone or in combination with inotropic agents in status 1 heart transplantcandidates as a pharmacological support until heart transplantation. Methods. Hemodynamic and biochemical variables were recorded in 29 status 1 men with symptoms of severe congestive heart failure, who received continuous intravenous milrinone alone (group 1, n = 21) or in combination with inotropic agents (group 2, n = 8) while awaiting heart transplantation. Results. Symptomatic relief was noted in all patients of both groups without any preoperative deaths. One patient (4.8%) of group 1 died on the second day and I patient of group 2 died 16.4 months after transplantation. Although pulmonary capillary wedge pressure (group 1, p = 0.021; group 2, p = 0.0002), mean pulmonary artery pressure (group 1, p = 0.051; group 2, p = 0.004), and pulmonary vascular resistance (group 1, p = 0.0026; group 2, p = 0.056) were reduced by 1 hour after the onset of treatment and maintained unchanged until transplantation, the changes in mean pulmonary artery pressure in group 1 and pulmonary vascular resistance in group 2 were statistically insignificant except in the posttransplantation period. Conclusions. Long-term therapy with milrinone in combination with inotropic agents is safe and effective when only milrinone infusion is inadequate for pharmacologic support in status 1 candidates. (C) 2000 by The Society ofThoracic Surgeons.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 04:41:02