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Titolo:
Differences in myocardial and peripheral VEGF and KDR levels after acute ischemia
Autore:
Miraliakbari, R; Francalancia, NA; Lust, RM; Gerardo, JA; Ng, PC; Sun, YS; Chitwood, WR;
Indirizzi:
E Carolina Univ, Sch Med, Dept Surg, Div Cardiothorac Surg, Greenville, NCUSA E Carolina Univ Greenville NC USA v Cardiothorac Surg, Greenville, NCUSA E Carolina Univ, Sch Med, Dept Physiol, Greenville, NC USA E Carolina Univ Greenville NC USA Med, Dept Physiol, Greenville, NC USA E Carolina Univ, Sch Med, Cardiothorac Res Labs, Greenville, NC USA E Carolina Univ Greenville NC USA diothorac Res Labs, Greenville, NC USA
Titolo Testata:
ANNALS OF THORACIC SURGERY
fascicolo: 6, volume: 69, anno: 2000,
pagine: 1750 - 1753
SICI:
0003-4975(200006)69:6<1750:DIMAPV>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOTHELIAL GROWTH-FACTOR; FACTOR RECEPTOR KDR; GENE-EXPRESSION; PHOSPHATIDYLINOSITOL 3-KINASE; THERAPEUTIC ANGIOGENESIS; HYPOXIA; PHVEGF(165); BINDING; CELLS; LIMB;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Francalancia, NA E Carolina Univ, Sch Med, Dept Surg, Div Cardiothorac Surg, 4S-22 Brody, Greenville, NC USA E Carolina Univ 4S-22 Brody Greenville NC USA le, NC USA
Citazione:
R. Miraliakbari et al., "Differences in myocardial and peripheral VEGF and KDR levels after acute ischemia", ANN THORAC, 69(6), 2000, pp. 1750-1753

Abstract

Background. Recent clinical use of vascular endothelial growth factor (VEGF) in the treatment of both myocardial and peripheral ischemia has suggested the possibility of tissue specific coregulation of VEGF and its receptors(eg, kinase domain region [KDR]). The present study was performed to detect the relationship between VEGF and KDR protein levels after acute myocardial and peripheral ischemia. Methods. Eleven dogs were divided into two groups: peripheral ischemia (n = 6,ligation of major limb arteries) and myocardial ischemia (n = 5, circsumflex artery ligation). Muscle biopsy specimens were taken from the perfusion territories of the occluded circumflex artery and limb arteries 3 hours and 6 hours after ligation. Protein levels were determined using Western blot analysis. Results. In myocardium, VEGF levels increased on average eightfold from baseline (p < 0.05) both 3 hours and 6 hours after occlusion, whereas myocardial KDR levels dropped by about 60% at 3 hours and 80% at 6 hours (p < 0.05). With limb ischemia, both VEGF and KDR levels were significantly elevatedat 3 hours. Conclusions. In acute ischemia, regulation of VEGF and KDR may be controlled differently in cardiac and skeletal muscle. Myocardial KDR levels showeda significant decrease from baseline compared with a significant rise withperipheral ischemia. (C) 2000 by The Society of Thoracic Surgeons.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 10:28:56