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Titolo:
TUMOR-NECROSIS-FACTOR-ALPHA AND LYMPHOTOXIN-ALPHA ARE NOT REQUIRED FOR INDUCTION OF ACUTE EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS
Autore:
FREI K; EUGSTER HP; BOPST M; CONSTANTINESCU CS; LAVI E; FONTANA A;
Indirizzi:
UNIV ZURICH HOSP,DEPT NEUROSURG,RAMISTR 100 CH-8091 ZURICH SWITZERLAND UNIV ZURICH HOSP,CLIN IMMUNOL SECT CH-8091 ZURICH SWITZERLAND ETH ZURICH,INST TOXICOL CH-8603 SCHWERZENBACH SWITZERLAND UNIV PENN,DEPT NEUROL PHILADELPHIA PA 19104 UNIV PENN,DEPT PATHOL,DIV NEUROPATHOL PHILADELPHIA PA 19104
Titolo Testata:
The Journal of experimental medicine
fascicolo: 12, volume: 185, anno: 1997,
pagine: 2177 - 2182
SICI:
0022-1007(1997)185:12<2177:TALANR>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS; CENTRAL-NERVOUS-SYSTEM; MYELIN BASIC-PROTEIN; LEWIS RATS; MULTIPLE-SCLEROSIS; FACTOR-BETA; EXPRESSION; CYTOKINES; MICE; DISEASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
K. Frei et al., "TUMOR-NECROSIS-FACTOR-ALPHA AND LYMPHOTOXIN-ALPHA ARE NOT REQUIRED FOR INDUCTION OF ACUTE EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS", The Journal of experimental medicine, 185(12), 1997, pp. 2177-2182

Abstract

Immunization of mice with myelin components results in experimental autoimmune encephalomyelitis (EAE), which is mediated by myelin-specific CD4(+) T cells and anti-myelin antibodies. Tumor necrosis factor alpha (TNF-alpha) and lymphotoxin alpha (LT-alpha) are thought to be involved in the events leading to inflammatory demyelination in the central nervous system. To ascertain this hypothesis 129 x C57BL/6 mice withan inactivation of the tnf and Ita genes (129 x C57BL/6(-/-)) and SJL/J mice derived h-om backcrosses of the above mentioned mutant mice (SJL(-/-)) were immunized with mouse spinal cord homogenate (MSCH) or proteolipid protein. Both 129 x C57BL/6(-/-) mice and SJL(-/-) mice developed EAE. In SJL(-/-) mice immunized with MSCH, a very severe form ofEAE with weight loss, paralysis of all four limbs, and lethal outcomewas observed. The histologic hallmark was an intense perivascular andparenchymal infiltration with predominantly CD4(+) T cells and some CD8(+) T cells associated with demyelination in both brain and spinal cord. These results indicate that TNF-alpha and LT-alpha are not essential for the development of EAE.

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Documento generato il 27/01/21 alle ore 02:20:24