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Titolo:
Prenatal exposure to famine and brain morphology in schizophrenia
Autore:
Hulshoff, HE; Hoek, HW; Susser, E; Brown, AS; Dingemans, A; Schnack, HG; van Haren, NEM; Ramos, LMP; Gispen-de Wied, CC; Kahn, RS;
Indirizzi:
Univ Utrecht, Med Ctr, Dept Psychiat A01126, NL-3584 CX Utrecht, Netherlands Univ Utrecht Utrecht Netherlands NL-3584 CX 3584 CX Utrecht, Netherlands Parnassia Psychomed Ctr, The Hague, Netherlands Parnassia Psychomed Ctr The Hague Netherlands r, The Hague, Netherlands The Hague Psychiat Inst, The Hague, Netherlands The Hague Psychiat Inst The Hague Netherlands t, The Hague, Netherlands Leiden Univ, Leiden, Netherlands Leiden Univ Leiden NetherlandsLeiden Univ, Leiden, Netherlands Columbia Univ, Joseph L Mailman Sch Publ Hlth, Div Epidemiol, New York, NYUSA Columbia Univ New York NY USA Publ Hlth, Div Epidemiol, New York, NYUSA
Titolo Testata:
AMERICAN JOURNAL OF PSYCHIATRY
fascicolo: 7, volume: 157, anno: 2000,
pagine: 1170 - 1172
SICI:
0002-953X(200007)157:7<1170:PETFAB>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Life Sciences
Citazioni:
12
Recensione:
Indirizzi per estratti:
Indirizzo: Hulshoff, HE Univ Utrecht, Med Ctr, Dept Psychiat A01126, Heidelberglaan 100, NL-3584 CX Utrecht, Netherlands Univ Utrecht Heidelberglaan 100 Utrecht Netherlands NL-3584 CX
Citazione:
H.E. Hulshoff et al., "Prenatal exposure to famine and brain morphology in schizophrenia", AM J PSYCHI, 157(7), 2000, pp. 1170-1172

Abstract

Objective: The authors assessed the effects of nutritional deficiency during the first trimester of pregnancy on brain morphology in patients with schizophrenia. Method: Nine schizophrenic patients and nine healthy comparison subjects exposed during the first trimester of gestation to the Dutch Hunger Winter were evaluated with magnetic resonance brain imaging, as were nine schizophrenic patients and nine healthy subjects who were not prenatally exposed to the famine. Results: Prenatal famine exposure in patients with schizophrenia was associated with decreased intracranial volume. Prenatal Hunger Winter exposure alone was related to an increase in brain abnormalities, predominantly whitematter hyperintensities. Conclusions: Nutritional deficiency during the first trimester of gestation resulted in an increase in clinical brain abnormalities and was associated with aberrant early brain development in patients with schizophrenia. Stunted brain development secondary to factors that affect brain growth duringthe first trimester of gestation may thus be a potential risk factor for developing schizophrenia.

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Documento generato il 18/02/20 alle ore 04:34:29