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Titolo:
Decreased benzodiazepine receptor binding in prefrontal cortex in combat-related posttraumatic stress disorder
Autore:
Bremner, JD; Innis, RB; Southwick, SM; Staib, L; Zoghbi, S; Charney, DS;
Indirizzi:
Yale Univ, Sch Med, VA Connecticut Healthcare Syst 115A, Dept Diagnost Radiol, W Haven, CT 06516 USA Yale Univ W Haven CT USA 06516 ept Diagnost Radiol, W Haven, CT 06516 USA Yale Univ, Sch Med, VA Connecticut Healthcare Syst 115A, Dept Psychiat, W Haven, CT 06516 USA Yale Univ W Haven CT USA 06516 115A, Dept Psychiat, W Haven, CT 06516 USA Natl Ctr PTSD, W Haven, CT USA Natl Ctr PTSD W Haven CT USANatl Ctr PTSD, W Haven, CT USA Yale Psychiat Inst, New Haven, CT USA Yale Psychiat Inst New Haven CT USA ale Psychiat Inst, New Haven, CT USA
Titolo Testata:
AMERICAN JOURNAL OF PSYCHIATRY
fascicolo: 7, volume: 157, anno: 2000,
pagine: 1120 - 1126
SICI:
0002-953X(200007)157:7<1120:DBRBIP>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON-EMISSION-TOMOGRAPHY; I-123 IOMAZENIL; PANIC DISORDER; SPECT MEASUREMENT; SWIM STRESS; HUMAN BRAIN; RAT; IODINE-123-IOMAZENIL; VETERANS; DIAZEPAM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Bremner, JD Yale Univ, Sch Med, VA Connecticut Healthcare Syst 115A, Dept Diagnost Radiol, 950 Campbell Ave, W Haven, CT 06516 USA Yale Univ 950 Campbell Ave W Haven CT USA 06516 , CT 06516 USA
Citazione:
J.D. Bremner et al., "Decreased benzodiazepine receptor binding in prefrontal cortex in combat-related posttraumatic stress disorder", AM J PSYCHI, 157(7), 2000, pp. 1120-1126

Abstract

Objective: Animals exposed to stress exhibit a decrease in benzodiazepine receptor binding in the frontal cortex. No studies have examined central benzodiazepine receptor binding in patients with posttraumatic stress disorder (PTSD). The purpose of this study was to examine measures of benzodiazepine receptor binding in PTSD. Method: From 13 patients with Vietnam combat-related PTSD and 13 case-matched healthy comparison subjects, a quantitative measure related to benzodiazepine receptor binding (distribution volume) was obtained with single photon emission computed tomography (SPECT) imaging of [I-123]iomazenil bindingand measurement of radioligand concentration in plasma. Distribution volume image data were analyzed by means of statistical parametric mapping. Results: Lower distribution volumes were found in the prefrontal cortex (Brodmann's area 9) of PTSD patients than in comparison subjects. Conclusions: These findings of lower values for the benzodiazepine receptor binding measure of distribution volume are consistent with fewer benzodiazepine receptors and/or reduced affinity of receptor binding in the medial prefrontal cortex in patients with PTSD. Alterations in benzodiazepine receptor function in this area may underlie many of the symptoms of PTSD.

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Documento generato il 19/01/20 alle ore 09:00:50