Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Brain SPECT imaging of amphetamine-induced dopamine release in euthymic bipolar disorder patients
Autore:
Anand, A; Verhoeff, P; Seneca, N; Zoghbi, SS; Seibyl, JP; Charney, DS; Innis, RB;
Indirizzi:
Yale Univ, Sch Med, Dept Psychiat, W Haven, CT 06516 USA Yale Univ W Haven CT USA 06516 Med, Dept Psychiat, W Haven, CT 06516 USA
Titolo Testata:
AMERICAN JOURNAL OF PSYCHIATRY
fascicolo: 7, volume: 157, anno: 2000,
pagine: 1108 - 1114
SICI:
0002-953X(200007)157:7<1108:BSIOAD>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
NONHUMAN-PRIMATES; IN-VIVO; SCHIZOPHRENIA; TRANSMISSION; BINDING; MANIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Anand, A Yale Univ, Sch Med, Dept Psychiat, 950 Campbell Ave, W Haven, CT 06516 USA Yale Univ 950 Campbell Ave W Haven CT USA 06516 ven, CT 06516 USA
Citazione:
A. Anand et al., "Brain SPECT imaging of amphetamine-induced dopamine release in euthymic bipolar disorder patients", AM J PSYCHI, 157(7), 2000, pp. 1108-1114

Abstract

Objective: Increased dopaminergic neurotransmission has been implicated inthe pathophysiology of bipolar disorder. However, it remains unclear whether the abnormality is due to increased dopamine release or enhanced postsynaptic receptor sensitivity. In this study, dopamine receptor imaging combined with a pharmacological challenge of amphetamine was used to assess both pre- and postsynaptic aspects of dopamine neurotransmission in euthymic bipolar disorder patients. Method: Thirteen patients with bipolar disorder (seven medication free andsix receiving mood stabilizer therapy) who had been euthymic for more than4 weeks and 13 age- and gender-matched healthy comparison subjects were included in the study. Single photon emission computed tomography scans were obtained with the striatal dopamine (D-2/ D-3) receptor radiotracer iodobenzamide ([I-123]IBZM) before and after an intravenous amphetamine challenge (0.3 mg/ kg). Reduction in striatal [I-123]IBZM binding potential from the first scan to the second scan was used as an indirect measure of the amountof dopamine released. Behavioral response to amphetamine was measured withthe Brief Psychiatric Rating Scale, Young Mania Rating Scale, and visual analogue scales. Results: Bipolar patients and healthy subjects did not differ in terms of mood state or striatal D-2 receptor binding at baseline. Amphetamine challenge led to a significantly greater behavioral response in bipolar patients than in healthy subjects. However, there was no significant difference between the two groups in the amphetamine-induced decrease in striatal [I-123]IBZM binding. Conclusions: In a group of euthymic patients with bipolar disorder, this study did not find evidence for increased striatal dopamine release. Instead, these data are consistent with enhanced postsynaptic dopamine responsivity in patients with bipolar disorder.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 22:23:08