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Titolo:
Sibling correlation of deficit syndrome in the Irish study of high-densityschizophrenia families
Autore:
Ross, DE; Kirkpatrick, B; Karkowski, LM; Straub, RE; MacLean, CJ; ONeill, FA; Compton, AD; Murphy, B; Walsh, D; Kendler, KS;
Indirizzi:
Virginia Commonwealth Univ, Med Coll Virginia, Virginia Inst Psychiat & Behav Genet, Dept Psychiat, Richmond, VA 23298 USA Virginia Commonwealth Univ Richmond VA USA 23298 , Richmond, VA 23298 USA Virginia Commonwealth Univ, Med Coll Virginia, Virginia Inst Psychiat & Behav Genet, Dept Human Genet, Richmond, VA 23298 USA Virginia Commonwealth Univ Richmond VA USA 23298 , Richmond, VA 23298 USA Mater Hosp, Dept Psychiat, Belfast, Antrim, North Ireland Mater Hosp Belfast Antrim North Ireland , Belfast, Antrim, North Ireland Queens Univ Belfast, Belfast BT7 1NN, Antrim, North Ireland Queens Univ Belfast Belfast Antrim North Ireland BT7 1NN m, North Ireland Hlth Res Board, Dublin, Ireland Hlth Res Board Dublin IrelandHlth Res Board, Dublin, Ireland
Titolo Testata:
AMERICAN JOURNAL OF PSYCHIATRY
fascicolo: 7, volume: 157, anno: 2000,
pagine: 1071 - 1076
SICI:
0002-953X(200007)157:7<1071:SCODSI>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
EYE TRACKING DYSFUNCTION; NEGATIVE SYMPTOMS; VULNERABILITY LOCUS; NONDEFICIT FORMS; NUCLEAR FAMILIES; DETECT LINKAGE; HETEROGENEITY; GENETICS; ABNORMALITIES; IMPAIRMENTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Life Sciences
Citazioni:
55
Recensione:
Indirizzi per estratti:
Indirizzo: Ross, DE Virginia Commonwealth Univ, Med Coll Virginia, Virginia Inst Psychiat & Behav Genet, Dept Psychiat, POB 980710, Richmond, VA 23298 USA Virginia Commonwealth Univ POB 980710 Richmond VA USA 23298 8 USA
Citazione:
D.E. Ross et al., "Sibling correlation of deficit syndrome in the Irish study of high-densityschizophrenia families", AM J PSYCHI, 157(7), 2000, pp. 1071-1076

Abstract

Objective: The deficit syndrome is a subtype of schizophrenia characterized by primary and enduring negative features of psychopathology. It appears to reflect a distinct subtype within the syndrome of schizophrenia. Little is known about the familial or genetic aspects of the deficit syndrome. Thepurpose of this study was to determine whether deficit versus nondeficit subtypes are correlated in sibling pairs affected with schizophrenia. Method: The present study was based on the Irish Study of High-Density Schizophrenia Families. From the earlier study the authors selected a subset of patients who were members of sibling pairs in which both siblings had been diagnosed with "core" schizophrenia, which included schizophrenia, simpleschizophrenia, and schizoaffective disorder with poor outcome. The Schedule for the Deficit Syndrome was used to make deficit versus nondeficit diagnoses, which were based on chart examinations by reviewers blind to sibling status. This method resulted in 65 patients being diagnosed with the deficit syndrome and 401 patients diagnosed as nondeficit (prevalence=13.9%). This group included 347 full sibling pairs, which were analyzed for resemblance with respect to deficit versus nondeficit subtype by means of logistic regression. Results: Deficit versus nondeficit subtypes were significantly correlated in sibling pairs concordant for core schizophrenia. Conclusions: Familial factors contribute significantly to whether a personhas the deficit subtype of schizophrenia. This familial contribution couldbe genetic or environmental.

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Documento generato il 28/03/20 alle ore 23:19:46