Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Hypertension and insulin resistant models have divergent propensities to learned helpless behavior in rodents
Autore:
Edwards, E; King, JA; Fray, J;
Indirizzi:
Univ Maryland, Sch Pharm, Dept Pharmaceut Sci, Baltimore, MD 21201 USA Univ Maryland Baltimore MD USA 21201 rmaceut Sci, Baltimore, MD 21201 USA Univ Massachusetts, Sch Med, Dept Psychiat, Worcester, MA 01655 USA Univ Massachusetts Worcester MA USA 01655 ychiat, Worcester, MA 01655 USA Univ Massachusetts, Sch Med, Dept Physiol, Worcester, MA USA Univ Massachusetts Worcester MA USA Med, Dept Physiol, Worcester, MA USA
Titolo Testata:
AMERICAN JOURNAL OF HYPERTENSION
fascicolo: 6, volume: 13, anno: 2000,
parte:, 1
pagine: 659 - 665
SICI:
0895-7061(200006)13:6<659:HAIRMH>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
DIABETES-MELLITUS; ANIMAL-MODEL; ZUCKER RAT; DEPRESSION; SYMPTOMS; DISEASE; STRESS;
Keywords:
hypertension; insulin resistance; depression; comorbidity; corticosterone; renin-angiotensin system; congenital learned helplessness; Zucker rats; Dahl rats;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Edwards, E Univ Maryland, Sch Pharm, Dept Pharmaceut Sci, Baltimore, MD 21201 USA Univ Maryland Baltimore MD USA 21201 , Baltimore, MD 21201 USA
Citazione:
E. Edwards et al., "Hypertension and insulin resistant models have divergent propensities to learned helpless behavior in rodents", AM J HYPERT, 13(6), 2000, pp. 659-665

Abstract

The induction of learned helpless (LH) behavior in rats is a widely used model of unipolar depression. Recent studies have linked depression with hypertension and insulin resistance as observed in obesity, but the propensityof these disorders to manifest depression has not been reported. In this study, the LH behavioral paradigm was exploited in a model of hypertension (Dahl rat) and of insulin resistance (Zucker rat) to determine the propensity of these models to develop depression and to examine the profile of markers for the propensity of the cardiovascular system (plasma renin activity) and of the hypothalamus-pituitary-adrenal axis (corticosterone) in the display of propensity to depression. Results show that Zucker rats displayed the lowest propensity to the development of LH behavior (12%), followed by the control Sprague-Dawley rats (27%), and then Dahl rats (66%). In contrast,congenital learned helpless (cLH) rats, a genetically bred strain for animal depression, had the highest propensity (>90%). A gender effect was observed in the Zucker and cLH rats, with females showing an increased propensity to develop LH behavior. Plasma renin activity in the Dahl and Sprague-Dawley rats after the LH stress paradigm was not significantly different from baseline. In contrast, Zucker rats, with the lowest propensity to LH behavior, demonstrated a threefold increase in plasma renin activity after stress. Congenital LH rats, with the highest propensity to LH behavior, exhibiteda significantly lower increase (43%) in plasma renin activity after stress. Hyporesponsive hypothalamus-pituitary-adrenal (HPA) axis functioning correlated with propensity of LH behavior. Stress-induced corticosterone levelsincreased under twofold in cLH rats, whereas they increased more than sevenfold in Zucker rats. Taken together, these studies suggest that whereas genetically prone hypertensive rats have a very high propensity to depression, insulin-resistant rats have a profound resistance to depression. Moreover, a hyporesponsive HPA axis may be a marker for disorders that are comorbidwith depression, whereas a hyperresponsive renin-angiotensin system may beindicative of resilience. Am J Hypertens 2000;13:659-665 (C) 2000 AmericanJournal of Hypertension, Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/08/20 alle ore 19:50:31