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Titolo:
Review article: effect of bile salt pool composition on hepatic and biliary functions
Autore:
Carulli, N; Bertolotti, M; Carubbi, F; Concari, M; Martella, P; Carulli, L; Loria, P;
Indirizzi:
Univ Modena, Dept Internal Med, I-41100 Modena, Italy Univ Modena ModenaItaly I-41100 ept Internal Med, I-41100 Modena, Italy
Titolo Testata:
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
, volume: 14, anno: 2000, supplemento:, 2
pagine: 14 - 18
SICI:
0269-2813(200005)14:<14:RAEOBS>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
LIPID SECRETION; CHOLESTEROL 7-ALPHA-HYDROXYLATION; RAT HEPATOCYTES; IN-VITRO; ACID; HUMANS; METABOLISM; GALLSTONES; APOPTOSIS; BALANCE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Carulli, L Univ Modena, Dept Internal Med, Via Pozzo 71, I-41100 Modena, Italy Univ Modena Via Pozzo 71 Modena Italy I-41100 00 Modena, Italy
Citazione:
N. Carulli et al., "Review article: effect of bile salt pool composition on hepatic and biliary functions", ALIM PHARM, 14, 2000, pp. 14-18

Abstract

The enterohepatic recirculation of bile salts exerts important regulatory effects on many hepatic, biliary and intestinal functions; such regulation is likely to depend, to a large extent, on the physical-chemical property of hydrophobicity of the recirculating pool. The present review summarizes the main experimental evidence carried out by our research group over the past two decades, in the attempt to investigate systematically the relationships between structural properties and biological effects of bile acids in humans. Hydrophobic bile acids (chenodeoxycholic acid, deoxycholic acid), but not hydrophilic acids (ursodeoxycholic acid), significantly suppressed hepatic activity of HMG-CoA reductase, the limiting step of cholesterol synthesis, and in vivo cholesterol 7 alpha-hydroxylation, the limiting step of bile acid synthesis. The output of biliary cholesterol and phospholipid was also directly related to the hydrophobicity of the bile acid pool. Finally,treatment with chenodeoxycholic acid, but not with ursodeoxycholic acid, significantly decreased gallbladder emptying rates. When turning to the in vitro model of HepG2 cells, hydrophobic bile acids were found to induce greater cytotoxic and pro-apoptotic effects. From this series of studies, we conclude that the regulatory effects of bile acids on the liver and biliary tract are largely dependent on the hydrophobic-hydrophilic balance of the recirculating bile acid pool.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 03:29:04