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Titolo:
Molecular evolution of oral poliovirus vaccine strains during multiplication in humans and possible implications for global eradication of poliovirus
Autore:
Friedrich, F;
Indirizzi:
FIOCRUZ, Inst Oswaldo Cruz, Dept Virol, BR-21040360 Rio De Janeiro, BrazilFIOCRUZ Rio De Janeiro Brazil BR-21040360 BC40360 Rio De Janeiro, Brazil
Titolo Testata:
ACTA VIROLOGICA
fascicolo: 2, volume: 44, anno: 2000,
pagine: 109 - 117
SICI:
0001-723X(200004)44:2<109:MEOOPV>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL-NERVOUS-SYSTEM; MONKEY KIDNEY-CELLS; PARALYTIC POLIOMYELITIS; SABIN TYPE-3; GENOMIC CHARACTERIZATION; TEMPERATURE SENSITIVITY; POSTPOLIO SYNDROME; GENETIC-BASIS; NONCODING REGION; POINT MUTATIONS;
Keywords:
poliovirus; poliomyelitis; oral poliovirus vaccine; poliomyelitis eradication; vaccine-derived polioviruses; mutation; recombination; deletion;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
76
Recensione:
Indirizzi per estratti:
Indirizzo: Friedrich, F FIOCRUZ, Inst Oswaldo Cruz, Dept Virol, BR-21040360 Rio De Janeiro, Brazil FIOCRUZ Rio De Janeiro Brazil BR-21040360 BCJaneiro, Brazil
Citazione:
F. Friedrich, "Molecular evolution of oral poliovirus vaccine strains during multiplication in humans and possible implications for global eradication of poliovirus", ACT VIROLOG, 44(2), 2000, pp. 109-117

Abstract

The oral poliovirus vaccine (OPV) has been effectively used in the controlof poliomyelitis and in the eradication of wild polioviruses. Although there are many advantages in using attenuated OPV strains in the campaign to eradicate poliomyelitis, several studies have demonstrated that there are some disadvantages such as (a) excretion by vaccines of OPV-derived polioviruses with genomic modifications known to increase the neurovirulence, (b) appearance of vaccine-associated paralytic poliomyelitis (VAPP) and other adverse effects in vaccinees, (c) occurrence of persistent infections caused by OPV-derived strains in immunodeficient patients with VAPP, (d) transmission of OPV-derived polioviruses to susceptible individuals which develop VAPP, and (e) detection of OPV-derived polioviruses in the environment, which could be a source of infection for humans in the future. Different studies indicate that it is important to consider the possibility of persistent infections and excretion of OPV-derived polioviruses for long periods by humans, and also the survival in the environment of OPV-derived polioviruses excreted by humans, which could be transmitted and circulate in a non-immune population after stopping poliovirus vaccination. The findings reported heremay have important implications for global poliomyelitis eradication initiative and indicate that surveillance of OPV-derived strains will also be important in the final step of eradication of poliomyelitis from the planet.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 21:31:16