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Titolo:
Attenuated endothelin-1 mRNA expression with endothelin-1 receptor blockade during hypoxaemia and reoxygenation in newborn piglets
Autore:
Medbo, S; Beisvag, V; Tollofsrud, PA; Ellingsen, O; Wright, MS;
Indirizzi:
Natl Hosp Norway, Dept Paediat Res, N-0027 Oslo, Norway Natl Hosp Norway Oslo Norway N-0027 ept Paediat Res, N-0027 Oslo, Norway Natl Hosp Norway, Inst Surg Res, N-0027 Oslo, Norway Natl Hosp Norway Oslo Norway N-0027 , Inst Surg Res, N-0027 Oslo, Norway Natl Hosp Norway, Sect Neonatol, N-0027 Oslo, Norway Natl Hosp Norway Oslo Norway N-0027 , Sect Neonatol, N-0027 Oslo, Norway Norwegian Univ Sci & Technol, Dept Physiol & Biomed Engn, Med Technol Ctr,N-7034 Trondheim, Norway Norwegian Univ Sci & Technol Trondheim Norway N-7034 4 Trondheim, Norway
Titolo Testata:
ACTA PAEDIATRICA
fascicolo: 6, volume: 89, anno: 2000,
pagine: 698 - 702
SICI:
0803-5253(200006)89:6<698:AEMEWE>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENE-EXPRESSION; CIRCULATING ENDOTHELIN-1; PULMONARY HEMODYNAMICS; PLASMA ENDOTHELIN-1; ET(B) RECEPTORS; CHRONIC HYPOXIA; NITRIC-OXIDE; POTENT; CELLS; ANTAGONISTS;
Keywords:
endothelin receptor blockade; ET-1 mRNA; lung tissue; pulmonary artery; SB 217242;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Medbo, S Natl Hosp Norway, Rikshosp, Dept Paediat Res, N-0027 Oslo, NorwayNatl Hosp Norway Oslo Norway N-0027 at Res, N-0027 Oslo, Norway
Citazione:
S. Medbo et al., "Attenuated endothelin-1 mRNA expression with endothelin-1 receptor blockade during hypoxaemia and reoxygenation in newborn piglets", ACT PAEDIAT, 89(6), 2000, pp. 698-702

Abstract

We investigated the cause of decreased plasma endothelin-1 (ET-1) during hypoxaemia and reoxygenation in newborn piglets subjected to simultaneous blocking of the ET-1 receptors. Changes in plasma ET-1 and prepro-ET-1 mRNA expression in the main pulmonary artery and the left lower lobe in the lung were studied in 1-2-d-old piglets. Ten minutes prior to hypoxaemia, the hypoxaemia group (n = 10) was given saline, two groups (both n = 9) were given1 and 5 mg/kg i.v. SB 217242 (an ET-1 receptor antagonist). Two groups served as normoxic controls, with and without SE 217242 5 mg/kg i.v. Hypoxaemia was induced by ventilating with 8% O-2 until base excess was <-20 mmol/l or mean arterial blood pressure was <20 mmHg. Reoxygenation was performed for 2 h with room air. During hypoxaemia, plasma ET-1 decreased in the hypoxaemia group, remained unchanged in the 1-mg group and increased in the 5-mggroup. At the end of reoxygenation, plasma ET-1 was above baseline in the 1-mg and 5-mg groups. In the pulmonary artery, the hypoxaemia,group showed 2- to 5-fold higher prepro-ET-1 mRNA expression compared to all the other groups (p < 0.05). There were trends for higher prepro-ET-l mRNA expression in pulmonary tissue in the hypoxaemia group compared to the two receptor-blocking groups (p < 0.07). Conclusions: We conclude that hypoxaemia and reoxygenation increase prepro-ET-1 mRNA expression in the pulmonary artery in newborn piglets. These observations suggest that the half-life of ET-1 is decreased during hypoxaemiaand reoxygenation in newborn piglets.

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Documento generato il 15/07/20 alle ore 05:19:11