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Titolo:
Serum neuron-specific enolase as a predictor of intracranial lesions in children with head trauma: A pilot study
Autore:
Fridriksson, T; Kini, N; Walsh-Kelly, C; Hennes, H;
Indirizzi:
Med Coll Wisconsin, Dept Pediat, Emergency Med Sect, Milwaukee, WI 53226 USA Med Coll Wisconsin Milwaukee WI USA 53226 d Sect, Milwaukee, WI 53226 USA
Titolo Testata:
ACADEMIC EMERGENCY MEDICINE
fascicolo: 7, volume: 7, anno: 2000,
pagine: 816 - 820
SICI:
1069-6563(200007)7:7<816:SNEAAP>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBROSPINAL-FLUID; INJURY; PROTEIN; DAMAGE; S-100;
Keywords:
children; head trauma; intracranial lesions; serum neuron-specific enolase; enolase;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
12
Recensione:
Indirizzi per estratti:
Indirizzo: Hennes, H Med Coll Wisconsin, Dept Pediat, Emergency Med Sect, 9000 W Wisconsin Ave,MS 677, Milwaukee, WI 53226 USA Med Coll Wisconsin 9000 W Wisconsin Ave,MS 677 Milwaukee WI USA 53226
Citazione:
T. Fridriksson et al., "Serum neuron-specific enolase as a predictor of intracranial lesions in children with head trauma: A pilot study", ACAD EM MED, 7(7), 2000, pp. 816-820

Abstract

Objective: To determine the reliability of serum neuron-specific enolase (NSE) levels in predicting intracranial lesions (ICL) in children with blunthead trauma (HT). Methods: A prospective pilot study was conducted of patients 0 to 18 years of age presenting to a children's hospital emergency department (ED) between December 1997 and October 1998. Children presenting within 24 hours of injury who required head computed tomography (CT) were eligible. Blood samples were obtained to measure serum NSE level. Data collected included patient demographics, historical information, Glasgow Coma Scale score (GCS), physical examination, head CT results, and outcome. Patientswere assigned to one of two groups based on the head CT results (PICL; presence of intracranial lesion, or NICL; no intracranial lesion). Data were analyzed using Student's t-test and chi-square. The 95% confidence interval (95% CI) was calculated when approximiate. A receiver operating characteristic curve was constructed to determine the NSE level that yielded the highest sensitivity and specificity for predicting ICL. Results: Fifty patients were enrolled; 22 (45%) had abnormal head CT. No difference in demographicsor mechanism of injury was observed between those with abnormal or normal CT scans. The mean GCS level was 11.9 +/- 4.2 for PICL and 13.9 +/- 2.6 forNICL (p = 0.045; 95% CI = -0.05 to -3.9). The mean NSE level was 26.7 +/- 21.4 for PICL and 17.7 +/- 7.8 for NICL (p = 0.048; 95% CI = 0.1 to 17.9). An NSE level greater than or equal to 15.3 ng/mL yielded a sensitivity of 77%, a specificity of 52%, and a negative predictive value of 74%. Conclusions: These results suggest that serum NSE may be a useful screening tool forpredicting ICL in children with blunt head trauma. However, the NSE alone was neither sensitive nor specific in predicting all patients with ICL.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 02:17:50