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Titolo:
CLINICAL CHARACTERISTICS OF JAPANESE MEN WITH GLUCOKINASE GENE BETA-CELL PROMOTER VARIANT
Autore:
YAMADA K; YUAN XH; ISHIYAMA S; ICHIKAWA F; KOYAMA K; KOYANAGI A; KOYAMA W; NONAKA K;
Indirizzi:
KURUME UNIV,SCH MED,DEPT MED,DIV ENDOCRINOL & METAB,67 ASAHIMACHI KURUME FUKUOKA 830 JAPAN KUMAMOTO RED CROSS,HLTH CARE CTR KUMAMOTO JAPAN
Titolo Testata:
Diabetes care
fascicolo: 7, volume: 20, anno: 1997,
pagine: 1159 - 1161
SICI:
0149-5992(1997)20:7<1159:CCOJMW>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEPENDENT DIABETES-MELLITUS; AMERICAN MEN; MUTATIONS; LINKAGE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
15
Recensione:
Indirizzi per estratti:
Citazione:
K. Yamada et al., "CLINICAL CHARACTERISTICS OF JAPANESE MEN WITH GLUCOKINASE GENE BETA-CELL PROMOTER VARIANT", Diabetes care, 20(7), 1997, pp. 1159-1161

Abstract

OBJECTIVE - To study the association between a variant at the position of -30 of beta-cell-specific promoter of the glucokinase gene and glucose tolerance in the Japanese general population and to assess the clinical characteristics of subjects with the variant. RESEARCH DESIGN AND METHODS - The genotype of 657 Japanese men aged 51.0 +/- 8.8 years(mean +/- SD) was analyzed by an allele-specific assay using polymerase chain reaction-restriction fragment length polymorphism. RESULTS - The variant allele frequency was 0.188 in subjects with normal glucosetolerance, 0.211 in subjects with impaired glucose tolerance, and 0.176 in diabetic subjects. In subjects with fasting plasma glucose levels <140 mg/dl, homozygous subjects for the promoter variant had significantly higher plasma glucose levels 60 min after oral glucose administration when compared with subjects without the variant allele. A cross-sectional analysis showed age-related elevation of basal glucose levels only in subjects without the promoter variant. Individuals heterozygous for the variant had significantly lower levels of HDL cholesterolthan normal subjects. HDL cholesterol values were lower in homozygouspeople than in normal and heterozygous subjects, although the differences were not statistically significant. CONCLUSIONS - The beta-cell promoter variant in homozygous state was associated with impaired glucose tolerance, but not with diabetes, and low HDL cholesterol levels inJapanese men. It is unlikely that the glucose intolerance associated with the promoter variant is progressive with age.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 20:46:25