Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Mechanisms of programmed cell death in the developing brain
Autore:
Kuan, CY; Roth, KA; Flavell, RA; Rakic, P;
Indirizzi:
Yale Univ, Sch Med, Neurobiol Sect, New Haven, CT 06510 USA Yale Univ NewHaven CT USA 06510 Neurobiol Sect, New Haven, CT 06510 USA Washington Univ, Sch Med, Dept Pathol, St Louis, MO 63110 USA Washington Univ St Louis MO USA 63110 Dept Pathol, St Louis, MO 63110 USA Yale Univ, Sch Med, Immunobiol Sect, Howard Hughes Med Inst, New Haven, CT06510 USA Yale Univ New Haven CT USA 06510 Hughes Med Inst, New Haven, CT06510 USA
Titolo Testata:
TRENDS IN NEUROSCIENCES
fascicolo: 7, volume: 23, anno: 2000,
pagine: 291 - 297
SICI:
0166-2236(200007)23:7<291:MOPCDI>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
BAX-DEFICIENT MICE; CYTOCHROME-C; BCL-X; NEURONAL DEATH; DNA FRAGMENTATION; CEREBRAL-CORTEX; NERVOUS-SYSTEM; KAPPA-B; IN-VIVO; APOPTOSIS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
57
Recensione:
Indirizzi per estratti:
Indirizzo: Kuan, CY Yale Univ, Sch Med, Neurobiol Sect, 333 Cedar St, New Haven, CT 06510 USA Yale Univ 333 Cedar St New Haven CT USA 06510 Haven, CT 06510 USA
Citazione:
C.Y. Kuan et al., "Mechanisms of programmed cell death in the developing brain", TRENDS NEUR, 23(7), 2000, pp. 291-297

Abstract

Programmed cell death (apoptosis) is an important mechanism that determines the size and shape of the vertebrate nervous system. Recent gene-targeting studies have indicated that homologs of the cell-death pathway in the nematode Caenorhabditis elegans have analogous functions in apoptosis in the developing mammalian brain. However, epistatic genetic analysis has revealedthat the apoptosis of progenitor cells during early embryonic development and apoptosis of postmitotic neurons at later stage of brain development have distinct roles and mechanisms. These results provide new insight on the significance and mechanism of neural cell death in mammalian brain development.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 17:36:45