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Titolo:
Solid supported high-throughput organic synthesis of peptide beta-turn mimetics via Petasis reaction/diketopiperazine formation
Autore:
Golebiowski, A; Klopfenstein, SR; Chen, JJ; Shao, X;
Indirizzi:
Proctor & Gamble Pharmaceut, Combinatorial Chem Grp, Hlth Care Res Ctr, Mason, OH 45040 USA Proctor & Gamble Pharmaceut Mason OH USA 45040 s Ctr, Mason, OH 45040 USA
Titolo Testata:
TETRAHEDRON LETTERS
fascicolo: 25, volume: 41, anno: 2000,
pagine: 4841 - 4844
SICI:
0040-4039(20000619)41:25<4841:SSHOSO>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTOR LIGANDS; DISCOVERY; ACID;
Keywords:
solid-phase synthesis; Petasis reaction; peptide beta-turn mimetics; combinatorial chemistry; bicyclic heterocyclic compounds;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Physical, Chemical & Earth Sciences
Citazioni:
11
Recensione:
Indirizzi per estratti:
Indirizzo: Golebiowski, A Proctor & Gamble Pharmaceut, Combinatorial Chem Grp, Hlth Care Res Ctr, 8700 Mason-Montgomery Rd,POB 8006, Mason, OH 45040 USA Proctor& Gamble Pharmaceut 8700 Mason-Montgomery Rd,POB 8006 Mason OH USA 45040
Citazione:
A. Golebiowski et al., "Solid supported high-throughput organic synthesis of peptide beta-turn mimetics via Petasis reaction/diketopiperazine formation", TETRAHEDR L, 41(25), 2000, pp. 4841-4844

Abstract

High-throughput organic synthesis of bicyclic diketopiperazines 1, beta-turn mimetics, is described. Starting from Merrifield resin-bound piperazine-2-carboxylic acid, first two (R-4 and R-5) Side chains are introduced via the Petasis reaction and subsequent amide bond formation. Unblocking the a-amino group of piperazine-2-carboxylic acid, Boc-N-protected alpha-amino acid coupling and deprotection followed by cyclative cleavage introduces the remaining R-2 and R-1 side chains. (C) 2000 Elsevier Science Ltd. All rightsreserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/10/20 alle ore 11:10:04