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Titolo:
Hypertonic/hyperoncotic resuscitation after intestinal superior mesentericartery occlusion: Early effects on circulation and intestinal reperfusion
Autore:
Jonas, J; Heimann, A; Strecker, U; Kempski, O;
Indirizzi:
Stadt Klinikum, Dept Surg, D-76133 Karlsruhe, Germany Stadt Klinikum Karlsruhe Germany D-76133 urg, D-76133 Karlsruhe, Germany Univ Mainz, Dept Anesthesia, D-55101 Mainz, Germany Univ Mainz Mainz Germany D-55101 Dept Anesthesia, D-55101 Mainz, Germany Univ Mainz, Inst Neurosurg Pathophysiol, D-55101 Mainz, Germany Univ Mainz Mainz Germany D-55101 rg Pathophysiol, D-55101 Mainz, Germany
Titolo Testata:
SHOCK
fascicolo: 1, volume: 14, anno: 2000,
pagine: 24 - 29
SICI:
1073-2322(200007)14:1<24:HRAISM>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
SMALL-VOLUME RESUSCITATION; HYPERTONIC SALINE DEXTRAN; REGIONAL BLOOD-FLOW; HEMORRHAGIC-SHOCK; ISCHEMIA-REPERFUSION; INJURY; PIGS; HEMODYNAMICS; NEUTROPHIL; RESPONSES;
Keywords:
mesenteric vascular occlusion; postischemic intestinal reperfusion; small volume resuscitation; laser doppler flowmetry; tonometry;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Jonas, J Dept Surg, Moltkestr 90, D-76133 Karlsruhe, Germany Dept Surg Moltkestr 90 Karlsruhe Germany D-76133 lsruhe, Germany
Citazione:
J. Jonas et al., "Hypertonic/hyperoncotic resuscitation after intestinal superior mesentericartery occlusion: Early effects on circulation and intestinal reperfusion", SHOCK, 14(1), 2000, pp. 24-29

Abstract

The objective of the study was to determine the early effects of hypertonic/hyperoncotic starch resuscitation after 2 h occlusion of the superior mesenteric artery (SMA) in comparison to animals reperfused without treatment and isotonic resuscitation. SMA was clamped (18 pigs, 19-23 kg) for 2 h followed by a 2-h reperfusion period, which was initiated with isotonic (ISO) (35 mL/kg 0.9% NaCl and 5 mL/kg 10% hydroxyethyl starch within 30 min) or hypertonic/hyperoncotic resuscitation (HHES) (7.5% NaCl/10% hydroxyethyl starch within 5 min). Cardiac output (CO), mean arterial blood pressure (MAP),serum lactate, antimesenteric serosal Laser-Doppler values (LD), and intramural pi-ii (tonometry) were measured. Without resuscitation at the onset of reperfusion MAP (70 +/- 3 mmHg) decreased to 40 +/- 3 mmHg and CO to 31% of baseline values after 30 min. Serum lactate increased to 5.1 +/- 1.6 mmol/L without improvement. The decrease of CO was attenuated only during the initial 30 min of reperfusion in the ISO group, but significantly better counteracted by hypertonic/hyperoncotic resuscitation. Without treatment, LD flow of the ileum (baseline 23-27 LD units) recovered but intramural pH (pHi) remained significantly decreased (7.26 +/- 0.05). With isotonic resuscitation LD Values (21.8 +/- 2.1 LD units) and intramural pHi (7.09 +/- 0.14) decreased even more (P < 0.05) whereas the HHES group showed a significant hyperemic reaction and a normalization of the intramural pHi and serum lactate within 30 min. Hypertonic/hyperoncotic resuscitation significantly improves MAP and CO during reperfusion shock and induces an immediate hyperemicreperfusion reaction of the intestinal microcirculation. Adequate isotonicfluid replacement in order to restore the postischemic plasma volume loss may cause a pronounced deterioration of intestinal perfusion.

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Documento generato il 05/07/20 alle ore 10:19:45