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Titolo:
Targeting of lysosomal proteins
Autore:
Rouille, Y; Rohn, W; Hoflack, B;
Indirizzi:
Inst Pasteur, CNRS, EP525, Inst Biol Lille, F-59021 Lille, France Inst Pasteur Lille France F-59021 Inst Biol Lille, F-59021 Lille, France
Titolo Testata:
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
fascicolo: 3, volume: 11, anno: 2000,
pagine: 165 - 171
SICI:
1084-9521(200006)11:3<165:TOLP>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
MANNOSE 6-PHOSPHATE RECEPTOR; TRANS-GOLGI NETWORK; KINASE-II PHOSPHORYLATION; AP-3 ADAPTER COMPLEX; IMMATURE SECRETORY GRANULES; POLARIZED EPITHELIAL-CELLS; TYROSINE-BASED MOTIF; CLATHRIN ADAPTER; SORTING SIGNALS; CYTOPLASMIC DOMAIN;
Keywords:
membrane traffic; protein sorting; adaptor complex; trans-Golgi network; endosomes; lysosomes;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
78
Recensione:
Indirizzi per estratti:
Indirizzo: Hoflack, B Inst Pasteur, CNRS, EP525, Inst Biol Lille, 1 Rue Prof Calmette,BP 447, F-59021 Lille, France Inst Pasteur 1 Rue Prof Calmette,BP 447 Lille France F-59021 e
Citazione:
Y. Rouille et al., "Targeting of lysosomal proteins", SEM CELL D, 11(3), 2000, pp. 165-171

Abstract

Proper cell homeostasis requires the efficient transport of a large variety of soluble acid hydrolases and transmembrane proteins from the trans-Golgi network (TGN) to lysosomes. While most of these molecules reach this degradative compartment, some transmembrane proteins, in particular the acid hydrolase receptors are retrieved to the TGN. This bidirectional transport process involves the formation of several vesicular transport intermediates in which cargo molecules are selectively packaged. This review summarizes our current understanding of the molecular mechanisms leading to the proper targeting of lysosomal proteins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 13:22:54