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Titolo:
The effects of clozapine on alcohol and drug use disorders among patients with schizophrenia
Autore:
Drake, RE; Xie, HY; McHugo, GJ; Green, AI;
Indirizzi:
New Hampshire Dartmouth Psychiat Res Ctr, Lebanon, NH USA New Hampshire Dartmouth Psychiat Res Ctr Lebanon NH USA Lebanon, NH USA Dartmouth Med Sch, Dept Community & Family Med, Lebanon, NH USA Dartmouth Med Sch Lebanon NH USA Community & Family Med, Lebanon, NH USA Massachusetts Mental Hlth Ctr, Commonwealth Res Ctr, Boston, MA 02115 USA Massachusetts Mental Hlth Ctr Boston MA USA 02115 r, Boston, MA 02115 USA Harvard Univ, Sch Med, Cambridge, MA 02138 USA Harvard Univ Cambridge MA USA 02138 niv, Sch Med, Cambridge, MA 02138 USA
Titolo Testata:
SCHIZOPHRENIA BULLETIN
fascicolo: 2, volume: 26, anno: 2000,
pagine: 441 - 449
SICI:
0586-7614(2000)26:2<441:TEOCOA>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEVERE MENTAL-ILLNESS; SUBSTANCE USE DISORDER; PSYCHIATRIC OUTPATIENTS; ABUSE TREATMENT; COMMUNITY; VALIDITY; SMOKING; RELIABILITY; HYPOTHESIS; MODELS;
Keywords:
schizophrenia; substance abuse; substance use disorder; clozapine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Drake, RE Psychiat Res Ctr, 2 Whipple Pl, Lebanon, NH 03766 USA Psychiat Res Ctr 2 Whipple Pl Lebanon NH USA 03766 NH 03766 USA
Citazione:
R.E. Drake et al., "The effects of clozapine on alcohol and drug use disorders among patients with schizophrenia", SCHIZO BULL, 26(2), 2000, pp. 441-449

Abstract

Several case studies indicate that clozapine use is associated with reductions in the use of nicotine, alcohol, or illicit drugs. Although not designed to assess clozapine, this study explored a posteriori the effects of clozapine on alcohol and drug use disorders among schizophrenia patients. Among 151 patients with schizophrenia or schizoaffective disorder and co-occurring substance use disorder who mere studied in a dual-disorder treatment program, 36 received clozapine during the study for standard clinical indications. All participants were assessed prospectively at baseline and every 6 months over 3 years for psychiatric symptoms and substance use, Alcohol-abusing patients taking clozapine experienced significant reductions in severity of alcohol abuse and days of alcohol use while on clozapine, For example, they averaged 54.1 drinking days during 6-month intervals while off clozapine and 12.5 drinking days while on clozapine, They also improved more than patients who did not receive clozapine, At the end of the study, 79.0 percent of the patients on clozapine mere in remission from alcohol use disorder for 6 months or longer, while only 33.7 percent of those not taking clozapine mere remitted. Findings related to other drugs in relation to clozapine were also positive but less clear because of the small number of patients with drug use disorders. This study was limited by the naturalistic design and the lack of prospective, standardized measures of clozapine use. The use of clozapine by patients with co-occurring substance disorders deservesfurther study in randomized clinical trials.

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Documento generato il 20/01/20 alle ore 16:28:19