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Titolo:
Erythrocyte-methotrexate and disease activity in children treated with oral methotrexate for juvenile chronic arthritis
Autore:
Kristensen, K; Nielsen, S; Pedersen, FK; Zak, M;
Indirizzi:
Rigshosp, Natl Univ Hosp, Juliane Marie Ctr, Paediat Clin 2, DK-2100 Copenhagen O, Denmark Rigshosp Copenhagen Denmark O diat Clin 2, DK-2100 Copenhagen O, Denmark
Titolo Testata:
SCANDINAVIAN JOURNAL OF RHEUMATOLOGY
fascicolo: 3, volume: 29, anno: 2000,
pagine: 187 - 189
SICI:
0300-9742(2000)29:3<187:EADAIC>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACUTE LYMPHOBLASTIC-LEUKEMIA; RHEUMATOID-ARTHRITIS; MAINTENANCE CHEMOTHERAPY; CHILDHOOD; THERAPY;
Keywords:
juvenile chronic arthritis; methotrexate; therapeutic drug monitoring;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
11
Recensione:
Indirizzi per estratti:
Indirizzo: Kristensen, K Rigshosp, Natl Univ Hosp, Juliane Marie Ctr, Paediat Clin 2,4064,Blegdamsvej 9, DK-2100 Copenhagen O, Denmark Rigshosp 4064,Blegdamsvej 9 Copenhagen Denmark O O, Denmark
Citazione:
K. Kristensen et al., "Erythrocyte-methotrexate and disease activity in children treated with oral methotrexate for juvenile chronic arthritis", SC J RHEUM, 29(3), 2000, pp. 187-189

Abstract

The concentration of methotrexate (MTX) in erythrocytes (E-MTX) was measured twice with three months interval in 21 children suffering from juvenile chronic arthritis (JCA). At the same time joint score, visual analogue scale NAS), and laboratory parameters (CRP. WBC, PMNs. and ALAT) were obtained. There was only a weak insignificant correlation between the dose of MTX/m(2) and E-MTX (r = 0.24, p=0.11). No significant relations between the clinical or laboratory parameters and E-MTX was found. However, ALAT above normal range was associated with a lower dose of MTX (p = 0.02) and lower VAS (p= 0.02), indicating that toxicity may be associated with less articular discomfort. At present we consider routine determination of E-MTX in childrenwith JCA of limited value.

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Documento generato il 02/06/20 alle ore 02:01:08