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Titolo:
SALUTARY EFFECT OF ADJUNCTIVE INTRACORONARY NICORANDIL ADMINISTRATIONON RESTORATION OF MYOCARDIAL BLOOD-FLOW AND FUNCTIONAL IMPROVEMENT INPATIENTS WITH ACUTE MYOCARDIAL-INFARCTION
Autore:
SAKATA Y; KODAMA K; KOMAMURA K; LIM YJ; ISHIKURA F; HIRAYAMA A; KITAKAZE M; MASUYAMA T; HORI M;
Indirizzi:
OSAKA POLICE HOSP,DIV CARDIOVASC,TENNOJI KU,10-31 KITAYAMA CHO OSAKA 543 JAPAN KAWACHI GEN HOSP,DIV CARDIOL HIGASHIOSAKA OSAKA JAPAN OSAKA UNIV,SCH MED,DEPT MED 1 SUITA OSAKA 565 JAPAN
Titolo Testata:
The American heart journal
fascicolo: 6, volume: 133, anno: 1997,
pagine: 616 - 621
SICI:
0002-8703(1997)133:6<616:SEOAIN>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
NO-REFLOW PHENOMENON; CONTRAST ECHOCARDIOGRAPHY; CORONARY-OCCLUSION; POTASSIUM CHANNELS; ISCHEMIA; PERFUSION; THROMBOLYSIS; DYSFUNCTION; REPERFUSION; VIABILITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
Y. Sakata et al., "SALUTARY EFFECT OF ADJUNCTIVE INTRACORONARY NICORANDIL ADMINISTRATIONON RESTORATION OF MYOCARDIAL BLOOD-FLOW AND FUNCTIONAL IMPROVEMENT INPATIENTS WITH ACUTE MYOCARDIAL-INFARCTION", The American heart journal, 133(6), 1997, pp. 616-621

Abstract

Salutary effect of nicorandil, a K+ adenosine triphosphate channel opener, on restoration of myocardial blood flow and functional improvement after coronary revascularization was investigated in 20 patients with first anterior acute myocardial infarction. Ten patients received intracoronary administration of nicorandil (2 mg) after coronary revascularization; the other 10 patients received coronary revascularizationonly and served as control subjects, Myocardial contrast echocardiography and two-dimensional echocardiography were performed to assess microvascular integrity and regional function in the infarcted area, Nicorandil improved peak contrast intensity ratio (p < 0.001), calculated as the ratio of peak contrast intensity in the infarcted and noninfarcted areas, indicating the restoration of myocardial blood flow to the infarcted myocardium. Regional wall motion improved more significantlyin 1 month in patients who received nicorandil (p < 0.01). Thus our results suggested the usefulness of intracoronary nicorandil administration after coronary revascularization for restoring blood flow and functional improvement in patients with acute myocardial infarction.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 14:43:23