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Titolo:
Antidepressants preferentially enhance habituation to novelty in the olfactory bulbectomized rat
Autore:
Mar, A; Spreekmeester, E; Rochford, J;
Indirizzi:
Douglas Hosp, Res Ctr, Verdun, PQ H4H 1R3, Canada Douglas Hosp Verdun PQ Canada H4H 1R3 Res Ctr, Verdun, PQ H4H 1R3, Canada McGill Univ, Dept Neurol & Neurosurg, Quebec City, PQ, Canada McGill UnivQuebec City PQ Canada l & Neurosurg, Quebec City, PQ, Canada McGill Univ, Dept Psychiat, Quebec City, PQ, Canada McGill Univ Quebec City PQ Canada Dept Psychiat, Quebec City, PQ, Canada
Titolo Testata:
PSYCHOPHARMACOLOGY
fascicolo: 1, volume: 150, anno: 2000,
pagine: 52 - 60
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAJOR DEPRESSIVE DISORDER; ELEVATED PLUS-MAZE; STRESS MODEL; BEHAVIOR; BRAIN; BUSPIRONE; PATTERN; DRUGS; AMITRIPTYLINE; IMIPRAMINE;
Keywords:
antidepressant; novelty; reactivity; habituation; open field; elevated plus maze; acoustic startle; random effects model; olfactory bulbectomized rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Rochford, J Douglas Hosp, Res Ctr, Lehmann Pavillon,6875 LaSalle Blvd, Verdun, PQ H4H 1R3, Canada Douglas Hosp Lehmann Pavillon,6875 LaSalle Blvd Verdun PQ Canada H4H 1R3
Citazione:
A. Mar et al., "Antidepressants preferentially enhance habituation to novelty in the olfactory bulbectomized rat", PSYCHOPHAR, 150(1), 2000, pp. 52-60

Abstract

exert their therapeutic effects remain unknown. Responses to stressful stimuli are currently thought to contribute to the onset and course of affective disorders. It has been postulated that antidepressants might act by ameliorating response patterns to challenging life events, such as processes ofreactivity and/or habituation. Objective: Using the olfactory bulbectomy (OBX) rat model, this study examined the effects of various antidepressants on measures of reactivity and habituation in behavioral tests assessing responses to novel stimuli. Methods: Sham-operated and OBX rats received 21 daily injections of fluoxetine (10 mg/kg), amitriptyline (10 mg/kg), desipramine (10 mg/kg), buspirone (3 mg/kg), or vehicle. Forty-eight hours after the last injection, animals were tested in the open field, elevated plus maze, and startle apparatus. For each test, time series data were collected andfit with exponential random effects models, in which estimated parameters assessed behavioral reactivity and habituation. Results: Relative to sham controls, OBX rats displayed increased total locomotor activity in the open field and exhibited increased open arm behavior in the elevated plus maze. Through comparison with zinc sulfate-treated anosmic controls, these OBX-induced increases were attributed to both an augmentation of initial reactivity due to anosmia and an attenuation of the average rate of habituation. Chronic antidepressant treatment did not reduce the anosmia-related initial reactivity levels of OBX rats to that of sham controls. Rather, the antidepressants evoked their restorative effects by increasing the rate of habituation. Conclusions: These Findings suggest that antidepressants restore normal responding by permitting more effective adaptation to novel stimuli.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 15:37:58