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Titolo:
EFFECTS OF THE AGED MICROENVIRONMENT ON CD4(-CELL MATURATION() T)
Autore:
THOMAN ML;
Indirizzi:
SCRIPPS CLIN & RES INST,DEPT IMMUNOL,IMM9,10666 N TORREY PINES RD LA JOLLA CA 92037
Titolo Testata:
Mechanism of ageing and development
fascicolo: 1-3, volume: 96, anno: 1997,
pagine: 75 - 88
SICI:
0047-6374(1997)96:1-3<75:EOTAMO>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
LYMPHOCYTES-T; MICE; CD4+; DIFFERENTIATION; EXPRESSION; SUBSETS; THYMUS; CENTENARIANS; PATTERNS; CD45RB;
Keywords:
CD4(+) T CELL; THYMOPOIESIS; MEMORY T CELL; NAIVE T CELL; IMMUNOSENESCENCE; T CELL MATURATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
M.L. Thoman, "EFFECTS OF THE AGED MICROENVIRONMENT ON CD4(-CELL MATURATION() T)", Mechanism of ageing and development, 96(1-3), 1997, pp. 75-88

Abstract

Contributing to the functional alterations of the aged immune system is the accumulation of memory CD4(+) T lymphocytes and decline in the proportion of naive cells occurring with advancing age. During attempts to alter the naive to memory ratio of CD4(+) cells in aged mice, it was observed that regeneration of the peripheral T cell compartment resulted in a population which possessed the same memory cell-enriched characteristics as the unmanipulated age-matched controls. Thymopoiesisin aged mice does not appear to be altered in such a way as to give rise to emigrants with 'memory-like' characteristics. The aged peripheral microenvironment does, however, cause the accelerated maturation ofmature, naive CD4(+) T cells to the memory state. (C) 1997 Elsevier Science Ireland Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 10:18:12