Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
MEK kinase 1 gene disruption alters cell migration and c-Jun NH2-terminal kinase regulation but does not cause a measurable defect in NF-kappa B activation
Autore:
Yujiri, T; Ware, M; Widmann, C; Oyer, R; Russell, D; Chan, E; Zaitsu, Y; Clarke, P; Tyler, K; Oka, Y; Fanger, GR; Henson, P; Johnson, GL;
Indirizzi:
Natl Jewish Med & Res Ctr, Program Mol Signal Transduct, Denver, CO 80206 USA Natl Jewish Med & Res Ctr Denver CO USA 80206 sduct, Denver, CO 80206 USA Yamaguchi Univ, Sch Med, Dept Internal Med 3, Yamaguchi, Japan Yamaguchi Univ Yamaguchi Japan d, Dept Internal Med 3, Yamaguchi, Japan Univ Colorado, Hlth Sci Ctr, Dept Neurol, Denver, CO 80262 USA Univ Colorado Denver CO USA 80262 Ctr, Dept Neurol, Denver, CO 80262 USA Univ Colorado, Hlth Sci Ctr, Dept Pharmacol, Denver, CO 80262 USA Univ Colorado Denver CO USA 80262 r, Dept Pharmacol, Denver, CO 80262 USA
Titolo Testata:
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
fascicolo: 13, volume: 97, anno: 2000,
pagine: 7272 - 7277
SICI:
0027-8424(20000620)97:13<7272:MK1GDA>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
EYELID DEVELOPMENT; STRESS FIBERS; ALPHA GENE; MOUSE; MICE; JNK; EXPRESSION; PHENOTYPE; PATHWAYS; RECEPTOR;
Keywords:
MEKK1; cell motility; JNK;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Johnson, GL Natl Jewish Med & Res Ctr, Program Mol Signal Transduct, Denver, CO 80206 USA Natl Jewish Med & Res Ctr Denver CO USA 80206 r, CO 80206 USA
Citazione:
T. Yujiri et al., "MEK kinase 1 gene disruption alters cell migration and c-Jun NH2-terminal kinase regulation but does not cause a measurable defect in NF-kappa B activation", P NAS US, 97(13), 2000, pp. 7272-7277

Abstract

MEK kinase 1 (MEKK1) is a 196-kDa mitogen-activated protein kinase (MAPK) kinase kinase that, in addition to regulating the c-Jun NH2-terminal kinase(JNK) pathway, is involved in the control of cell motility. MEKK1(-/-) mice are defective in eyelid closure, a TGF alpha-directed process involving the migration of epithelial cells. MEKK1 expression in epithelial cells stimulates lamellipodia formation, a process required for cell movement. In addition, mouse embryo fibroblasts derived from MEKK1(-/-) mice are inhibited in their migration relative to MEKK1(+/+) fibroblasts. MEKK1 is required for JNK but not NF-kappa B activation in response to virus infection, microtubule disruption, and stimulation of embryonic stem cells with lysophosphatidic acid. MEKK1 is not required for TNF alpha or IL-1 regulation of JNK or NF-kappa B activation in macrophages or fibroblasts. Thus, MEKK1 senses microtubule integrity, contributes to the regulation of fibroblast and epithelial cell migration, and is required for activation of JNK but not NF-kappa B in response to selected stress stimuli.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 10:02:59