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Titolo:
Development of early melanocytic lesions in transgenic mice predisposed tomelanoma
Autore:
Zhu, H; Reuhl, K; Botha, R; Ryan, K; Wei, J; Chen, SZ;
Indirizzi:
Rutgers State Univ, Dept Biol Chem, Canc Res Lab, Coll Pharm, Piscataway, NJ 08854 USA Rutgers State Univ Piscataway NJ USA 08854 harm, Piscataway, NJ 08854 USA Rutgers State Univ, Coll Pharm, Dept Pharmacol & Toxicol, Piscataway, NJ 08854 USA Rutgers State Univ Piscataway NJ USA 08854 icol, Piscataway, NJ 08854 USA
Titolo Testata:
PIGMENT CELL RESEARCH
fascicolo: 3, volume: 13, anno: 2000,
pagine: 158 - 164
SICI:
0893-5785(200006)13:3<158:DOEMLI>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
MALIGNANT-MELANOMA; CUTANEOUS MELANOMA; SKIN MELANOMA; MOUSE; FIBROBLASTS; BIOLOGY; CANCER; MODEL; GENE; RAS;
Keywords:
insertion mutagenesis; melanocytes; spontaneous skin lesion;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Chen, SZ Rutgers State Univ, Dept Biol Chem, Canc Res Lab, Coll Pharm, Piscataway, NJ 08854 USA Rutgers State Univ Piscataway NJ USA 08854 cataway, NJ 08854 USA
Citazione:
H. Zhu et al., "Development of early melanocytic lesions in transgenic mice predisposed tomelanoma", PIGM CELL R, 13(3), 2000, pp. 158-164

Abstract

We have previously described a line of transgenic mice (TG3) that spontaneously develops heritable malignant melanoma. Histological analysis of theseanimals during the first postnatal month is described here. In the TG3 line, the number of melanocytes is increased at all anatomical sites to which neural-crest-derived melanocytes normally migrate. Clonal expansion and morphological changes of these melanocytes can be detected as early as postnatal day (PND) 15. By PND 30, cells morphologically indistinguishable from the tumor cells of adult transgenic mice were detected in the ear, eye lid and perianal region. These cells are believed to be the precursors of the primary tumors in adult mice. The stepwise development of melanoma in the TG3 line is similar to the stepwise development of melanoma in humans.

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Documento generato il 28/11/20 alle ore 09:19:38