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Titolo:
Garlic and neem leaf extracts enhance hepatic glutathione and glutathione dependent enzymes during N-methyl-N '-nitro-N-nitrosoguanidine (MNNG)-induced gastric carcinogenesis in rats
Autore:
Arivazhagan, S; Balasenthil, S; Nagini, S;
Indirizzi:
Annamalai Univ, Dept Biochem, Annamalainagar 608002, Tamil Nadu, India Annamalai Univ Annamalainagar Tamil Nadu India 608002 , Tamil Nadu, India
Titolo Testata:
PHYTOTHERAPY RESEARCH
fascicolo: 4, volume: 14, anno: 2000,
pagine: 291 - 293
SICI:
0951-418X(200006)14:4<291:GANLEE>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
CANCER; CONSTITUENTS; ANTIOXIDANTS; TRANSFERASES; TOXICITY;
Keywords:
garlic; neem; N-methyl-N '-nitro-N-nitrosoguanidine; gastric cancer; chemoprevention; lipid peroxidation; antioxidants; glutathione; liver;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Nagini, S Annamalai Univ, Dept Biochem, Annamalainagar 608002, Tamil Nadu,India Annamalai Univ Annamalainagar Tamil Nadu India 608002 du, India
Citazione:
S. Arivazhagan et al., "Garlic and neem leaf extracts enhance hepatic glutathione and glutathione dependent enzymes during N-methyl-N '-nitro-N-nitrosoguanidine (MNNG)-induced gastric carcinogenesis in rats", PHYTOTHER R, 14(4), 2000, pp. 291-293

Abstract

The protective effect of garlic (Allium sativum L,) and neem leaf (Azadirachta indica A. Juss.) was investigated on hepatic lipid peroxidation and antioxidant status during N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-inducedgastric carcinogenesis in male Wistar rats, Enhanced lipid peroxidation inthe liver of tumour-bearing animals was accompanied by significant decreases in the activities of glutathione peroxidase (GPx), glutathione-S-transferase (GST), gamma-glutamyl transpeptidase (GGT) and reduced glutathione (GSH) levels. Administration of garlic and neem leaf extracts significantly lowered lipid peroxidation and enhanced the hepatic levels of glutathione andglutathione dependent enzymes, We speculate that garlic and neem leaf significantly alter cancer development at extrahepatic sites by influencing hepatic biotransformation enzymes and antioxidants. Copyright 2000 John Wiley & Sons, Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/10/20 alle ore 04:33:20